Evidence map›Paper›PMID 29461122›Full record

ArticleDrug delivery2018

Synchronous delivery of oxygen and photosensitizer for alleviation of hypoxia tumor microenvironment and dramatically enhanced photodynamic therapy.

Xiaomeng Guo, Jiaxin Qu, Chunqi Zhu, Wei Li, Lihua Luo, Jie Yang, Xiaoyi Yin, Qingpo Li, Yongzhong Du, Dawei Chen and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Drug delivery, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 91 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Emerging Nanoplatforms are Effective Against Tumor Hypoxia.International journal of nanomedicine · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Xiaomeng Guoa College of Pharmaceutical Sciences , Zhejiang University , Hangzhou , Zhejiang , P. R. China.
Jiaxin Qua College of Pharmaceutical Sciences , Zhejiang University , Hangzhou , Zhejiang , P. R. China.
Chunqi Zhua College of Pharmaceutical Sciences , Zhejiang University , Hangzhou , Zhejiang , P. R. China.
Wei Lia College of Pharmaceutical Sciences , Zhejiang University , Hangzhou , Zhejiang , P. R. China.
Lihua Luoa College of Pharmaceutical Sciences , Zhejiang University , Hangzhou , Zhejiang , P. R. China.
Jie Yanga College of Pharmaceutical Sciences , Zhejiang University , Hangzhou , Zhejiang , P. R. China.
Xiaoyi Yinb Department of Pharmaceutics , School of Pharmaceutical Science, Shenyang Pharmaceutical University , Shenyang , Liaoning , P. R. China.
Qingpo Lia College of Pharmaceutical Sciences , Zhejiang University , Hangzhou , Zhejiang , P. R. China.
Yongzhong Dua College of Pharmaceutical Sciences , Zhejiang University , Hangzhou , Zhejiang , P. R. China.
Dawei Chenb Department of Pharmaceutics , School of Pharmaceutical Science, Shenyang Pharmaceutical University , Shenyang , Liaoning , P. R. China.
Yunqing Qiuc State Key Laboratory for Diagnosis and Treatment of Infectious Diseases , Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University , Hangzhou , Zhejiang , P. R. China.
Yan Louc State Key Laboratory for Diagnosis and Treatment of Infectious Diseases , Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University , Hangzhou , Zhejiang , P. R. China.
Jian Youa College of Pharmaceutical Sciences , Zhejiang University , Hangzhou , Zhejiang , P. R. China.
Zhejiang University · CNShenyang Pharmaceutical University · CNFirst Affiliated Hospital Zhejiang University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Photosensitizer, proper laser irradiation, and oxygen are essential components for effective photodynamic therapy (PDT) in clinical cancer therapy. However, native hypoxic tumoral microenvironment is a major barrier hindering photodynamic reactions in vivo. Thus, we have prepared biocompatible liposomes by loading complexes of oxygen-carrier (hemoglobin, Hb) and photosensitizer (indocyanine green, ICG) for enhanced PDT against hypoxic tumor. Ideal oxygen donor Hb, which is an oxygen-carried protein in red blood cells, makes such liposome which provide stable oxygen supply. ICG, as a photosensitizer, could transfer energy from lasers to oxygen to generate cytotoxic reactive oxygen species (ROS) for treatment. The liposomes loading ICG and Hb (LIH) exhibited efficient tumor homing upon intravenous injection. As revealed by T

Indexed as

AnimalsCell Line, TumorHumansHypoxiaHypoxia-Inducible Factor 1, alpha SubunitIndocyanine GreenLiposomesMaleMiceMice, Inbred BALB CMice, Inbred ICROxygenPhotochemotherapyPhotosensitizing AgentsReactive Oxygen SpeciesTumor MicroenvironmentHypoxia-Inducible Factor 1, alpha SubunitIndocyanine GreenLiposomesOxygenPhotosensitizing AgentsReactive Oxygen SpeciesVascular Endothelial Growth Factor Ahemoglobinoxygenphotodynamic therapyphotosensitizerTumor hypoxia

Identifiers

PMID29461122
PMCPMC6058564
OpenAlexW2793664782

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.