ArticleNMR in biomedicine2018
Towards an analytic solution for pulsed CEST.
Article in NMR in biomedicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- A rapid and accurate guanidine CEST imaging in ischemic stroke using a machine learning approach.Physics in medicine and biology · 2026Article
- Quantitative macromolecular proton fraction imaging using pulsed spin-lock.Magnetic resonance in medicine · 2025Article
- Improving quantification accuracy of a nuclear Overhauser enhancement signal at -1.6 ppm at 4.7 T using a machine learning approach.Physics in medicine and biology · 2025Article
- Enhancing amide proton transfer imaging in ischemic stroke using a machine learning approach with partially synthetic data.NMR in biomedicine · 2025Article
- Adjustment of rotation and saturation effects (AROSE) for CEST imaging.Magnetic resonance in medicine · 2024Article
- Numerical simulation-based assessment of pH-sensitive chemical exchange saturation transfer MRI quantification accuracy across field strengths.NMR in biomedicine · 2023Article
- Detection of tissue pH with quantitative chemical exchange saturation transfer magnetic resonance imaging.NMR in biomedicine · 2023Review
- Mapping pH using stimulated echoes formed via chemical exchange.Magnetic resonance imaging · 2022Article
- Average saturation efficiency filter (ASEF) for CEST imaging.Magnetic resonance in medicine · 2022Article
- An end-to-end AI-based framework for automated discovery of rapid CEST/MT MRI acquisition protocols and molecular parameter quantification (AutoCEST).Magnetic resonance in medicine · 2022Article
- A hybrid numeric-analytic solution for pulsed CEST.NMR in biomedicine · 2022Article
- Quasi-steady-state CEST (QUASS CEST) solution improves the accuracy of CEST quantification: QUASS CEST MRI-based omega plot analysis.Magnetic resonance in medicine · 2021Article
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Authors and funding
4 authors.
Funding
Abstract
Chemical exchange saturation transfer (CEST) is an imaging method based on magnetization exchange between solutes and water. This exchange generates changes in the measured signal after off-resonance radiofrequency irradiation. Although the analytic solution for CEST with continuous wave (CW) irradiation has been determined, most studies are performed using pulsed irradiation. In this work, we derive an analytic solution for the CEST signal after pulsed irradiation that includes both short-time rotation effects and long-time saturation effects in a two-pool system corresponding to water and a low-concentration exchanging solute pool. Several approximations are made to balance the accuracy and simplicity of the resulting analytic form, which is tested against numerical solutions of the coupled Bloch equations and is found to be largely accurate for amides at high fields, but less accurate at the higher exchange rates, lower offsets and typically higher irradiation powers of amines.
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