Observational studyAllergy2018
Angioedema in chronic spontaneous urticaria is underdiagnosed and has a substantial impact: Analyses from ASSURE-CSU.
Observational study in Allergy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
52 citing papers in PubMed, 1 synthesis or guideline pooled it, 104 citations in OpenAlex.
- The prevelance of food allergy in patients with chronic idiopathic urticaria: a systematic review and meta-analysis.Archives of dermatological research · 2024Pooled it
- Effect of combining histaglobulin with antihistamines in patients with chronic spontaneous urticaria in a tertiary care hospital setting- a randomized trial.Archives of dermatological research · 2025Trial
- Angioedema Presenting as Infant-Onset Primary Lymphedema.Journal of vascular anomalies · 2026Article
- Research on chronic urticaria and angioedema: A bibliometric analysis of Web of Science Core Collection.Immunologic research · 2026Review
- Immunological Basis of Chronic Spontaneous Urticaria: Immunoglobulin E and Beyond.Yonsei medical journal · 2026Review
- Identifying and Evaluating Patient-Centered Mobile and Web Apps for Patients With Chronic Spontaneous Urticaria: Systematic Search and Content Analysis.JMIR mHealth and uHealth · 2026Article
- Heterogeneity in clinical appearance of chronic spontaneous urticaria: A cross-sectional analysis of a retrospective cohort.The World Allergy Organization journal · 2026Article
- Psychological Wellbeing of Patients with Chronic Spontaneous Urticaria and Its Relation to Their Overall Health-Related Quality of Life.Clinical, cosmetic and investigational dermatology · 2026Article
- Prevalence, treatment and burden of chronic spontaneous urticaria in five European countries.Journal of the European Academy of Dermatology and Venereology : JEADV · 2025Article
- Clinical profile, prevalence, and burden of chronic spontaneous urticaria in the United States.The World Allergy Organization journal · 2025Article
- Urticaria Voices: Real-World Experience of Patients Living with Chronic Spontaneous Urticaria.Dermatology and therapy · 2025Article
- Prevalence and Burden of Chronic Spontaneous Urticaria in Japan: A Cross-Sectional Study.Journal of clinical medicine · 2025Article
- Assesment of Salivary and Serum Levels of HBD2 in Patients with Chronic Angioedema.Journal of clinical medicine · 2024Article
- Does angioedema in patients with chronic spontaneous urticaria impact response to omalizumab?The World Allergy Organization journal · 2024Article
- Disease Control and Treatment Satisfaction in Patients with Chronic Spontaneous Urticaria in Japan.Journal of clinical medicine · 2024Article
- Hereditary angioedema with normal C1 inhibitor associated with carboxypeptidase N deficiency.The journal of allergy and clinical immunology. Global · 2024Article
- Impact of Chronic Spontaneous or Inducible Urticaria on Occupational Activity.Acta dermato-venereologica · 2024Observational
- Monitoring recurrent angioedema: Findings from the Turkish angioedema control test validation study.Clinical and translational allergy · 2024Article
- Risk calculator of the clinical response to antihistamines in chronic urticaria: Development and internal validation.PloS one · 2024Article
- Omalizumab for Patients with Chronic Spontaneous Urticaria: A Narrative Review of Current Status.Dermatology and therapy · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
23 authors at 17 institutions in 10 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundASSURE-CSU revealed differences in physician and patient reporting of angioedema. This post hoc analysis was conducted to evaluate the actual rate of angioedema in the study population and explore differences between patients with and without angioedema.
methodsThis international observational study assessed 673 patients with inadequately controlled chronic spontaneous urticaria (CSU). Physicians abstracted angioedema data from medical records, which were compared with patient-reported data. Patients in the Yes-angioedema category had angioedema reported in the medical record and a patient-reported source. For those in the No-angioedema category, angioedema was reported in neither the medical record nor a patient-reported source. Those in the Misaligned category had angioedema reported in only one source. Statistical comparisons between Yes-angioedema and No-angioedema categories were conducted for measures of CSU activity, health-related quality of life (HRQoL), productivity and healthcare resource utilization (HCRU). Regression analyses explored the relationship between Dermatology Life Quality Index (DLQI) score and angioedema, adjusting for important covariates.
resultsAmong evaluable patients, 259 (40.3%), 173 (26.9%) and 211 (32.8%) were in the Yes-angioedema, No-angioedema and Misaligned category, respectively. CSU activity and impact on HRQoL, productivity, and HCRU was greater for Yes-angioedema patients than No-angioedema patients. After covariate adjustment, mean DLQI score was significantly higher (indicating worse HRQoL) for patients with angioedema versus no angioedema (9.88 vs 7.27, P < .001). The Misaligned category had similar results with Yes-angioedema on all outcomes.
conclusionsAngioedema in CSU seems to be under-reported but has significant negative impacts on HRQoL, daily activities, HCRU and work compared with no angioedema.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.