Evidence map›Paper›PMID 29460720›Full record

ArticleComparative medicine2018

Humane Endpoints for Guinea Pigs Used for

Chereen Collymore, Laura Kent, Sang Kyun Ahn, Wenxi Xu, Ming Li, Jun Liu, Patricia V Turner, E Kate Banks

Abstract readObservational Study, Veterinary
PubMed Full text at PMC
In one paragraph

Article in Comparative medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Investigation of Various Intramuscular Volumes Delivered to the Semimembranosus Muscle ofJournal of the American Association for Laboratory Animal Science : JAALAS · 2020
    Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Chereen CollymoreDivision of Comparative Medicine, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada;, Email: c.collymore@utoronto.ca.
Laura KentDivision of Comparative Medicine, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
Sang Kyun AhnDepartments of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.
Wenxi XuPrincess Margaret Cancer Center, Immune Therapy Program, University Health Network, Toronto, Ontario, Canada.
Ming LiDepartments of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.
Jun LiuDepartments of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.
Patricia V TurnerDepartment of Pathobiology, University of Guelph, Guelph, Ontario, Canada.
E Kate BanksDivision of Comparative Medicine, Faculty of Medicine, Departments of Physiology, University of Toronto, Toronto, Ontario, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Guinea pigs are a commonly used model for tuberculosis vaccine research. Loss of body weight is the most frequently described humane endpoint for animals used in these studies. During a chronic study, we noted labored breathing in some tuberculosis-infected guinea pigs. To develop consistent humane endpoints for these guinea pigs, we performed an observational study using multiple clinical signs. A combination of body weight loss, labored breathing, and activity level during handling estimated the time to euthanasia within approximately 7 d. Histologic severity scores of lesions in the cranial or caudal lung lobe (or both) supported clinical endpoints. This study presents humane endpoints for the refinement of studies using guinea pigs in tuberculosis research.

Indexed as

Animal WelfareEuthanasia, AnimalTuberculosis VaccinesAnimalsDyspneaFemaleGuinea PigsMycobacterium tuberculosisWeight LossTuberculosis Vaccines

Identifiers

PMID29460720
PMCPMC5824138

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.