ArticleProceedings of the National Academy of Sciences of the United States of America1986
17 beta-estradiol regulates and v-Ha-ras transfection constitutively enhances MCF7 breast cancer cell interactions with basement membrane.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1986. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 112 citations in OpenAlex.
- The Relevance of Common K-RAS Gene Mutations and K-RAS mRNA Expression with Clinicopathological Findings and Survival in Breast Cancer.Asian Pacific journal of cancer prevention : APJCP · 2023Article
- Breast Cancer Reconstruction: Design Criteria for a Humanized Microphysiological System.Tissue engineering. Part A · 2021Article
- RAS as Supporting Actor in Breast Cancer.Frontiers in oncology · 2019Review
- Personalized in vitro cancer models to predict therapeutic response: Challenges and a framework for improvement.Pharmacology & therapeutics · 2016Review
- Discordant cellular response to presurgical letrozole in bilateral synchronous ER+ breast cancers with a KRAS mutation or FGFR1 gene amplification.Molecular cancer therapeutics · 2012Article
- Article
- Expression patterns of ER, HER2, and NM23-H1 in breast cancer patients with different menopausal status: correlations with metastasis.Molecular diagnosis & therapy · 2011Article
- S-nitrosylation at cysteine 498 of c-Src tyrosine kinase regulates nitric oxide-mediated cell invasion.The Journal of biological chemistry · 2010Article
- Role of estrogens and their receptors in adhesion and invasiveness of breast cancer cells.Advances in experimental medicine and biology · 2008Article
- Integrated transcriptome analysis of the cellular mechanisms associated with Ha-ras-dependent malignant transformation of the human breast epithelial MCF7 cell line.Nucleic acids research · 2003Article
- Overexpression of ROCK in human breast cancer cells: evidence that ROCK activity mediates intracellular membrane traffic of lysosomes.Pathology oncology research : POR · 2003Article
- Sodium phenylacetate enhances the inhibitory effect of dextran derivative on breast cancer cell growth in vitro and in nude mice.British journal of cancer · 2001Article
- Malignant transformation alters intracellular trafficking of lysosomal cathepsin D in human breast epithelial cells.Pathology oncology research : POR · 1998Article
- The invasion-MTT assay as a predictor of liver metastasis using human gastrointestinal carcinomas transplanted in nude mice.Surgery today · 1997Article
- Aberrant function of the Ras signal transduction pathway in human breast cancer.Breast cancer research and treatment · 1995Review
- Cathepsin B and D are Localized at the Surface of Human Breast Cancer Cells.Pathology oncology research : POR · 1995Article
- Oncogene-induced basement membrane invasiveness in human mammary epithelial cells.Clinical & experimental metastasis · 1994Article
- Estradiol enhances leukocyte binding to tumor necrosis factor (TNF)-stimulated endothelial cells via an increase in TNF-induced adhesion molecules E-selectin, intercellular adhesion molecule type 1, and vascular cell adhesion molecule type 1.The Journal of clinical investigation · 1994Article
- Cyclic AMP decreases chemotaxis, invasiveness and lung colonization of H-ras transformed mouse fibroblasts.Clinical & experimental metastasis · 1993Article
- Expression of 67 kDa laminin receptor in human breast cancer cells: regulation by progestins.Clinical & experimental metastasis · 1993Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The interaction of a line of human breast carcinoma cells (MCF7) with basement membrane components, particularly laminin, was altered by exposure of the cells to estrogen as well as by transfection of the cells with the v-Ha-ras oncogene. In both cases, the cells show a greater ability to attach to a laminin substrate, to migrate to laminin, to grow in the presence of a basement membrane matrix, and to cross barriers of reconstituted basement membrane. These responses were associated with an increase in the expression of laminin receptors. It is postulated that the increase in the invasive behavior of the cells treated with estrogen or transfected with v-Ha-ras is related to the increased number of laminin receptors and their interaction with laminin. Estrogen had no discernible effect on the v-Ha-ras transfected cells. It appears that in the MCF7 cells, the malignant phenotype is under hormonal control and that this control is bypassed after v-Ha-ras transfection.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.