Evidence map›Paper›PMID 29460269›Full record

ArticleMolecular neurobiology2018

Novel Defense by Metallothionein Induction Against Cognitive Decline: From Amyloid β

Atsushi Takeda, Haruna Tamano, Wakana Hashimoto, Shuhei Kobuchi, Hiroki Suzuki, Taku Murakami, Munekazu Tempaku, Yuta Koike, Paul A Adlard, Ashley I Bush

Open access · greenAbstract read
PubMed Publisher
In one paragraph

Article in Molecular neurobiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.7field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
  2. Article
  3. Isoproterenol, an adrenergic β receptor agonist, induces metallothionein synthesis followed by canceling amyloid βBiometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2022
    Article
  4. Article
  5. TPEN attenuates amyloid-βMolecular brain · 2021
    Article
  6. Dehydroeffusol Pprevents Amyloid βMolecular neurobiology · 2021
    Article
  7. Extracellular ZnBiological trace element research · 2021
    Review
  8. Article
  9. Amyloid βMolecular neurobiology · 2019
    Article
  10. Intracellular ZnScientific reports · 2019
    Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Atsushi TakedaDepartment of Neurophysiology, School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka, 422-8526, Japan. takedaa@u-shizuoka-ken.ac.jp.ORCID http://orcid.org/0000-0001-7519-2957
Haruna TamanoDepartment of Neurophysiology, School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka, 422-8526, Japan.
Wakana HashimotoDepartment of Neurophysiology, School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka, 422-8526, Japan.
Shuhei KobuchiDepartment of Neurophysiology, School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka, 422-8526, Japan.
Hiroki SuzukiDepartment of Neurophysiology, School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka, 422-8526, Japan.
Taku MurakamiDepartment of Neurophysiology, School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka, 422-8526, Japan.
Munekazu TempakuDepartment of Neurophysiology, School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka, 422-8526, Japan.
Yuta KoikeDepartment of Neurophysiology, School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka, 422-8526, Japan.
Paul A AdlardThe Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, VIC, 3052, Australia.
Ashley I BushThe Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, VIC, 3052, Australia.
University of Shizuoka · JPThe University of Melbourne · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The role of metallothioneins (MTs) in cognitive decline associated with intracellular Zn

Indexed as

AgingAmyloid beta-PeptidesAnimalsCognitive DysfunctionDexamethasoneHumansIntracellular SpaceLong-Term PotentiationMaleMetallothioneinPeptide FragmentsRats, WistarZincAmyloid beta-Peptidesamyloid beta-protein (1-42)DexamethasoneMetallothioneinPeptide FragmentsZincAlzheimer’s diseaseAmyloid β1-42Cognitive declineDentate gyrusExtracellular Zn2+Metallothionein

Identifiers

PMID29460269
OpenAlexW2794257754

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.