ArticleJournal of industrial microbiology & biotechnology2018
Rational design and analysis of an Escherichia coli strain for high-efficiency tryptophan production.
Article in Journal of industrial microbiology & biotechnology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 46 citations in OpenAlex.
- Biosensor-driven evolution and metabolic engineering of an Escherichia coli cell factory for L-tryptophan production.Microbial cell factories · 2026Article
- Integrated transcriptomic and metabolomic analyses uncover novel genetic targets for enhanced l-tryptophan production inSynthetic and systems biotechnology · 2026Article
- Optimizing L-Tryptophan Production inJournal of microbiology and biotechnology · 2025Article
- Recent Advances in Metabolic Engineering for the Biosynthesis of Phosphoenol Pyruvate-Oxaloacetate-Pyruvate-Derived Amino Acids.Molecules (Basel, Switzerland) · 2024Review
- Efficient production of phenyllactic acid inFrontiers in microbiology · 2024Article
- Transcriptomics and metabolomics analysis of L-phenylalanine overproduction in Escherichia coli.Microbial cell factories · 2023Article
- Natural and engineered cyclodipeptides: Biosynthesis, chemical diversity, and engineering strategies for diversification and high-yield bioproduction.Engineering microbiology · 2023Review
- Biosensor development for single-cell detection of glucuronate.Journal of industrial microbiology & biotechnology · 2023Article
- A comprehensive review and comparison of L-tryptophan biosynthesis inFrontiers in bioengineering and biotechnology · 2023Review
- Metabolic control analysis enables rational improvement of E. coli L-tryptophan producers but methylglyoxal formation limits glycerol-based production.Microbial cell factories · 2022Article
- Advances and prospects in metabolic engineering of Escherichia coli for L-tryptophan production.World journal of microbiology & biotechnology · 2022Review
- Metabolic control analysis of L-tryptophan producing Escherichia coli applying targeted perturbation with shikimate.Bioprocess and biosystems engineering · 2021Article
- Analyzing the genetic characteristics of a tryptophan-overproducing Escherichia coli.Bioprocess and biosystems engineering · 2021Article
- Integrated laboratory evolution and rational engineering of GalP/Glk-dependentMetabolic engineering communications · 2021Article
- EngineeringSynthetic and systems biotechnology · 2020Article
- Metabolic engineering for improving L-tryptophan production in Escherichia coli.Journal of industrial microbiology & biotechnology · 2019Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
L-tryptophan (L-trp) is a precursor of various bioactive components and has great pharmaceutical interest. However, due to the requirement of several precursors and complex regulation of the pathways involved, the development of an efficient L-trp production strain is challenging. In this study, Escherichia coli (E. coli) strain KW001 was designed to overexpress the L-trp operator sequences (trpEDCBA) and 3-deoxy-D-arabinoheptulosonate-7-phosphate synthase (aroG
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Registered trials
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