Evidence map›Paper›PMID 29459869›Full record

ArticleFrontiers in immunology2018

Fcµ Receptor Promotes the Survival and Activation of Marginal Zone B Cells and Protects Mice against Bacterial Sepsis.

Jun Liu, Hanying Zhu, Jiawen Qian, Ermeng Xiong, Lumin Zhang, Yan-Qing Wang, Yiwei Chu, Hiromi Kubagawa, Takeshi Tsubata, Ji-Yang Wang

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.

  1. Pooled it
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  7. Microorganisms · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 3 countries.

Jun LiuDepartment of Immunology, School of Basic Medical Sciences, Fudan University, Shanghai, China.
Hanying ZhuDepartment of Immunology, School of Basic Medical Sciences, Fudan University, Shanghai, China.
Jiawen QianDepartment of Immunology, School of Basic Medical Sciences, Fudan University, Shanghai, China.
Ermeng XiongDepartment of Immunology, School of Basic Medical Sciences, Fudan University, Shanghai, China.
Lumin ZhangDepartment of Immunology, School of Basic Medical Sciences, Fudan University, Shanghai, China.
Yan-Qing WangDepartment of Integrative Medicine and Neurobiology, School of Basic Medical Sciences; Institute of Acupuncture and Moxibustion, Fudan Institutes of Integrative Medicine, Fudan University, Shanghai, China.
Yiwei ChuDepartment of Immunology, School of Basic Medical Sciences, Fudan University, Shanghai, China.
Hiromi KubagawaDeutsches Rheuma-Forschungszentrum Berlin, Berlin, Germany.
Takeshi TsubataDepartment of Immunology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan.
Ji-Yang WangDepartment of Immunology, School of Basic Medical Sciences, Fudan University, Shanghai, China.
Fudan University · CNTokyo Medical and Dental University · JPGerman Rheumatism Research Centre · DEShanghai Medical College of Fudan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The marginal zone B cells (MZB) are located at the interface between the circulation and lymphoid tissue and as a gatekeeper play important roles in both innate and adaptive immune responses. We have previously found that MZB are significantly reduced in mice deficient in the IgM Fc receptor (FcμR) but how FcμR regulates the development and function of MZB remains unknown. In this study, we found that both marginal zone precursor (MZP) and MZB were decreased in

Indexed as

Lymphocyte ActivationAnimalsApoptosisB-LymphocytesCitrobacter rodentiumEnterobacteriaceae InfectionsGene Expression RegulationImmunity, HumoralLymphoid TissueMiceMice, KnockoutReceptors, FcSepsisSpleenimmunoglobulin M receptorReceptors, FcapoptosisFcµ receptorhumoral immune responsemarginal zone B celltonic BCR signal

Identifiers

PMID29459869
PMCPMC5807594
OpenAlexW2791328101

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.