ArticleFrontiers in immunology2018
The Immune and Non-Immune Pathways That Drive Chronic Gastrointestinal Helminth Burdens in the Wild.
Article in Frontiers in immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed.
- Environmental drivers of low vaccine responsiveness in a lab-to-wild rodent model.PLoS pathogens · 2026Article
- Immunity to helminths in complex environments: co-infection disrupts effective granuloma formation and parasite clearance.Discovery immunology · 2026Article
- Exploring Genetic Factors Associated withAnimals : an open access journal from MDPI · 2025Article
- Acquired immunity mechanisms in sheep infected withFrontiers in veterinary science · 2025Article
- Extracellular vesicles: an emerging tool for wild immunology.Discovery immunology · 2024Review
- Genetic and Environmental interactions contribute to immune variation in rewilded mice.bioRxiv : the preprint server for biology · 2023Article
- The genome sequence of the wood mouse,Wellcome open research · 2023Article
- Long-term temporal trends in gastrointestinal parasite infection in wild Soay sheep.Parasitology · 2022Article
- Monocytes maintain central nervous system homeostasis following helminth-induced inflammation.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- The IL-25-dependent tuft cell circuit driven by intestinal helminths requires macrophage migration inhibitory factor (MIF).Mucosal immunology · 2022Article
- Long-term trends in helminth infections of wood mice (Parasitology · 2021Article
- Gene expression response to a nematode parasite in novel and native eel hosts.Ecology and evolution · 2019Article
- Variation in Local and Systemic Pro-Inflammatory Immune Markers of Wild Wood Mice after Anthelmintic Treatment.Integrative and comparative biology · 2019Article
- Prediction of mosquito species and population age structure using mid-infrared spectroscopy and supervised machine learning.Wellcome open research · 2019Article
- Fueling Defense: Effects of Resources on the Ecology and Evolution of Tolerance to Parasite Infection.Frontiers in immunology · 2018Review
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Parasitic helminths are extremely resilient in their ability to maintain chronic infection burdens despite (or maybe because of) their hosts' immune response. Explaining how parasites maintain these lifelong infections, identifying the protective immune mechanisms that regulate helminth infection burdens, and designing prophylactics and therapeutics that combat helminth infection, while preserving host health requires a far better understanding of how the immune system functions in natural habitats than we have at present. It is, therefore, necessary to complement mechanistic laboratory-based studies with studies on wild populations and their natural parasite communities. Unfortunately, the relative paucity of immunological tools for non-model species has held these types of studies back. Thankfully, recent progress in high-throughput 'omics platforms provide powerful and increasingly practical means for immunologists to move beyond traditional lab-based model organisms. Yet, assigning both metabolic and immune function to genes, transcripts, and proteins in novel species and assessing how they interact with other physiological and environmental factors requires identifying quantitative relationships between their expression and infection. Here, we used supervised machine learning to identify gene networks robustly associated with burdens of the gastrointestinal nematode
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Registered trials
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