Evidence map›Paper›PMID 29459836›Full record

ArticleFrontiers in psychiatry2018

Treating Depression with Transcutaneous Auricular Vagus Nerve Stimulation: State of the Art and Future Perspectives.

Jian Kong, Jiliang Fang, Joel Park, Shaoyuan Li, Peijing Rong

3 registry-linked trialsOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in psychiatry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 103 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
103citing papers in PubMed, 6 pooled it
9.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04100486 enrolling by invitationnot on this mapstarted 2019, after this paper: background citation

A Pilot Study to Quantify the Autonomic Nervous System Balance in Healthy, Able-Bodied Individuals

TypeobservationalSponsorNorthwell HealthRan2019 to 2027Enrolled48ConditionsAutonomic Dysfunction, Autonomic Imbalance, Autonomic Nervous System Diseases, Vagus Nerve Autonomic DisorderArmsStanding-Squatting-Standing Test, Deep Breathing Test, Cold Pressor Test, Cold Face Test, Valsalva Maneuver
NCT04938687 completednot on this mapstarted 2022, after this paper: background citation

Pilot, Effect of Respiratory-Gated Auricular Vagal Afferent Nerve Stimulation (RAVANS) on Post-Treatment Lyme Disease Syndrome

TypeinterventionalSponsorSpaulding Rehabilitation HospitalRan2022 to 2025Enrolled15ConditionsPost-Treatment Lyme Disease SyndromeArmsrespiratory-gated auricular vagal afferent nerve stimulation (RAVANS), Sham RAVANS
NCT05343039 nacompletednot on this mapstarted 2022, after this paper: background citation

Leveraging Biomarkers and New Technologies to Reduce Self-Injury and Substance Abuse Risk Among Highly Vulnerable Adolescents

TypeinterventionalSponsorUniversity of Notre DameRan2022 to 2025Enrolled30ConditionsNonsuicidal Self Injury, Alcohol Abuse, Vagus Nerve StimulationArmsNon-invasive Transcutaneous Nerve Stimulation (tVNS), No Intervention
3 · Its place in the literature

Who cites it

103 citing papers in PubMed, 6 syntheses or guidelines pooled it, 194 citations in OpenAlex.

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43 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Jian KongPsychiatry Department, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, United States.
Jiliang FangGuang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
Joel ParkPsychiatry Department, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, United States.
Shaoyuan LiInstitute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing, China.
Peijing RongInstitute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing, China.
Chinese Academy of Medical Sciences & Peking Union Medical College · CNHarvard University · US

Funding

The Role of Context Effect in Acupuncture Treatment of Low Back/J.KongP01AT006663 · NCCIH · MASSACHUSETTS GENERAL HOSPITAL · PI HIRSCHTICK, RANDY L, ROSEN, BRUCE R · 2011 to 2017
$10.0M
Neuromodulation of placebo and nocebo effectsR01AT008563 · NCCIH · MASSACHUSETTS GENERAL HOSPITAL · PI KONG, JIAN · 2015 to 2019
$3.9M
The Neurobiology of Placebo and Nocebo Effects: A Brain Imaging StudyR01AT006364 · NCCIH · MASSACHUSETTS GENERAL HOSPITAL · PI KONG, JIAN · 2011 to 2015
$3.6M
Tai Chi Mind-body Exercise for the Treatment of Post-traumatic Stress DisorderR01AT006367 · NCCIH · TUFTS MEDICAL CENTER · PI WANG, CHENCHEN · 2011 to 2014
$2.9M
Mentoring and Research in Patient-Oriented Integrative MedicineK24AT007323 · NCCIH · TUFTS MEDICAL CENTER · PI WANG, CHENCHEN · 2014 to 2023
$1.8M
Mechanistic Studies on video guided acupuncture imagery treatment of painR61AT009310 · NCCIH · MASSACHUSETTS GENERAL HOSPITAL · PI KONG, JIAN · 2016 to 2017
$845k
Neural dynamics of directly and indirectly conditioned placebo/nocebo effectR21AT008707 · NCCIH · MASSACHUSETTS GENERAL HOSPITAL · PI KONG, JIAN · 2016 to 2017
$479k
NCCIH NIH HHS K24 AT007323NCCIH NIH HHS P01 AT006663NCCIH NIH HHS R01 AT006364NCCIH NIH HHS R01 AT006367NCCIH NIH HHS R01 AT008563NCCIH NIH HHS R21 AT008707NCCIH NIH HHS R61 AT009310
6 · The paper itself

Abstract

Depression is a highly prevalent disorder, and its treatment is far from satisfactory. There is an urgent need to develop a new treatment for depression. Although still at its early stage, transcutaneous auricular vagus nerve stimulation (taVNS) has shown promising potential for treating depression. In this article, we first summarize the results of clinical studies on the treatment effect of taVNS on depression. Then, we re-analyze a previous study to identify the specific symptoms taVNS can relieve as indicated by subscores of the 24-item Hamilton Depression Scale in patients with depression. We found that taVNS can significantly reduce multiple symptoms of depression patients, including anxiety, psychomotor retardation, sleep disturbance, and hopelessness. Next, we pose several hypotheses on the mechanism of taVNS treatment of depression, including directly and indirectly modulating the activity and connectivity of key brain regions involved in depression and mood regulation; inhibiting neuro-inflammatory sensitization; modulating hippocampal neurogenesis; and regulating the microbiome-brain-gut axis. Finally, we outline current challenges and lay out the future directions of taVNS treatment of depression, which include (1) intensively comparing stimulation parameters and "dose effect" (treatment frequency and duration) to maximize the treatment effect of taVNS; (2) exploring the effect of taVNS on disorders comorbid with depression (such as chronic pain disorders, cardiovascular disorder, and autism) to provide new "two-for-one" treatment approaches for patients with these disorders; and (3) applying multiple scale methods to explore the underlying mechanism of taVNS.

Indexed as

anti-inflammationbrain networkdepressiontranscutaneous auricular vagus nerve stimulationtranscutaneous vagus nerve stimulationvagus nerve

Identifiers

PMID29459836
PMCPMC5807379
OpenAlexW2794294466

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.