ArticleScientific reports2018
Serum Metabolomics of Activity Energy Expenditure and its Relation to Metabolic Syndrome and Obesity.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 2 syntheses or guidelines pooled it, 47 citations in OpenAlex.
- Metabolomics in Exercise and Sports: A Systematic Review.Sports medicine (Auckland, N.Z.) · 2022Pooled it
- Metabolomic profiles of being physically active and less sedentary: a critical review.Metabolomics : Official journal of the Metabolomic Society · 2021Pooled it
- Leisure-time physical activity and metabolomic trajectories over the transition from late midlife to old age.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026Article
- Determinants of the plasma metabolome: cross-sectional and longitudinal associations over six years in the NESDA cohort.EBioMedicine · 2026Article
- Higher plasma serine levels are associated with favorable values of metabolic health markers among middle-aged and older adults in The Maastricht Study.GeroScience · 2026Article
- Metabolic Profiles of Feline Obesity Revealed by Untargeted and Targeted Mass Spectrometry-Based Metabolomics Approaches.Veterinary sciences · 2025Article
- Physical activity, metabolites, and breast cancer associations.Journal of the National Cancer Institute · 2025Article
- Nontargeted and targeted metabolic profile of metabolic syndrome patients: a study based on Yi and Han populations in Yunnan.Frontiers in endocrinology · 2025Article
- Macrophages and T cells in metabolic disorder-associated cancers.Nature reviews. Cancer · 2024Review
- Plasma Metabolomics Study on the Impact of Different CRF Levels on MetS Risk Factors.Metabolites · 2024Article
- Metabolic liability for weight gain in early adulthood.Cell reports. Medicine · 2024Article
- Multiomics Picture of Obesity in Young Adults.Biology · 2024Article
- Exploring Metabolic and Gut Microbiome Responses to Paraquat Administration in Male Wistar Rats: Implications for Oxidative Stress.Antioxidants (Basel, Switzerland) · 2024Article
- Metabolomics to Understand Alterations Induced by Physical Activity during Pregnancy.Metabolites · 2023Review
- Serum Metabolome Adaptations Following 12 Weeks of High-Intensity Interval Training or Moderate-Intensity Continuous Training in Obese Older Adults.Metabolites · 2023Article
- Research advances in the application of metabolomics in exercise science.Frontiers in physiology · 2023Review
- Insight into the Molecular Signature of Skeletal Muscle Characterizing Lifelong Football Players.International journal of environmental research and public health · 2022Article
- Association of Cardiovascular Health Through Young Adulthood With Genome-Wide DNA Methylation Patterns in Midlife: The CARDIA Study.Circulation · 2022Article
- Metabolomics prospect of obesity and metabolic syndrome; a systematic review.Journal of diabetes and metabolic disorders · 2022Review
- Investigation into potential mechanisms of metabolic syndrome by integrative analysis of metabolomics and proteomics.PloS one · 2022Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
Modifiable lifestyle factors, including exercise and activity energy expenditure (AEE), may attenuate the unfavorable health effects of obesity, such as risk factors of metabolic syndrome (MetS). However, the underlying mechanisms are not clear. In this study we sought to investigate whether the metabolite profiles of MetS and adiposity assessed by body mass index (BMI) and central obesity are inversely correlated with AEE and physical activity. We studied 35 men and 47 women, aged 30-60 years, using doubly labeled water to derive AEE and the Sedentary Time and Activity Reporting Questionnaire (STAR-Q) to determine the time spent in moderate and vigorous physical activity. Proton nuclear magnetic resonance spectroscopy was used for serum metabolomics analysis. Serine and glycine were found in lower concentrations in participants with more MetS risk factors and greater adiposity. However, serine and glycine concentrations were higher with increasing activity measures. Metabolic pathway analysis and recent literature suggests that the lower serine and glycine concentrations in the overweight/obese state could be a consequence of serine entering de novo sphingolipid synthesis. Taken together, higher levels of AEE and physical activity may play a crucial part in improving metabolic health in men and women with and without MetS risk factors.
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Registered trials
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