ArticleScientific reports2018
Maturation State and Matrix Microstructure Regulate Interstitial Cell Migration in Dense Connective Tissues.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 41 citations in OpenAlex.
- Adipose-mimetic granular hydrogels uncover biophysical cues driving breast cancer invasion.Cell biomaterials · 2026Article
- Biologic Augmentation for Meniscus Repair: A Narrative Review.Bioengineering (Basel, Switzerland) · 2026Review
- Rapid restoration of cell phenotype and matrix forming capacity following transient nuclear softening.Acta biomaterialia · 2025Article
- Adipose-mimetic granular hydrogels uncover biophysical cues driving breast cancer invasion.bioRxiv : the preprint server for biology · 2025Article
- Excess surface area of the nuclear lamina enables unhindered cell migration through constrictions.Science advances · 2025Article
- Hydrogel Design to Understand and Guide 3D Cell Migration.Regenerative engineering and translational medicine · 2025Review
- Microinterfaces in biopolymer-based bicontinuous hydrogels guide rapid 3D cell migration.Nature communications · 2024Article
- A novel on-a-chip system with a 3D-bioinspired gut mucus suitable to investigate bacterial endotoxins dynamics.Materials today. Bio · 2024Article
- Healthy but not osteoarthritic human meniscus-derived matrix scaffolds promote meniscus repair.Frontiers in bioengineering and biotechnology · 2024Article
- Transient inhibition of meniscus cell migration following acute inflammatory challenge.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2023Article
- Histological Analysis of Regenerative Properties in Human Glenoid Labral Regions.The American journal of sports medicine · 2023Article
- Article
- A hydrogel spinal dural patch with potential anti-inflammatory, pain relieving and antibacterial effects.Bioactive materials · 2022Article
- A review of strategies for development of tissue engineered meniscal implants.Biomaterials and biosystems · 2021Review
- Six-Month Outcomes of Clinically Relevant Meniscal Injury in a Large-Animal Model.Orthopaedic journal of sports medicine · 2021Review
- A biofabrication method to align cells within bioprinted photocrosslinkable and cell-degradable hydrogel constructs via embedded fibers.Biofabrication · 2021Article
- Recellularization and Integration of Dense Extracellular Matrix by Percolation of Tissue Microparticles.Advanced functional materials · 2021Article
- Intrinsic and growth-mediated cell and matrix specialization during murine meniscus tissue assembly.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021Article
- Histologically Confirmed Recellularization is a Key Factor that Affects Meniscal Healing in Immature and Mature Meniscal Tears.Frontiers in cell and developmental biology · 2021Article
- Advances in the Mechanisms Affecting Meniscal Avascular Zone Repair and Therapies.Frontiers in cell and developmental biology · 2021Review
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
Few regenerative approaches exist for the treatment of injuries to adult dense connective tissues. Compared to fetal tissues, adult connective tissues are hypocellular and show limited healing after injury. We hypothesized that robust repair can occur in fetal tissues with an immature extracellular matrix (ECM) that is conducive to cell migration, and that this process fails in adults due to the biophysical barriers imposed by the mature ECM. Using the knee meniscus as a platform, we evaluated the evolving micromechanics and microstructure of fetal and adult tissues, and interrogated the interstitial migratory capacity of adult meniscal cells through fetal and adult tissue microenvironments with or without partial enzymatic digestion. To integrate our findings, a computational model was implemented to determine how changing biophysical parameters impact cell migration through these dense networks. Our results show that the micromechanics and microstructure of the adult meniscus ECM sterically hinder cell mobility, and that modulation of these ECM attributes via an exogenous matrix-degrading enzyme permits migration through this otherwise impenetrable network. By addressing the inherent limitations to repair imposed by the mature ECM, these studies may define new clinical strategies to promote repair of damaged dense connective tissues in adults.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.