Evidence map›Paper›PMID 29459662›Full record

ArticleLeukemia2018

Blast phase myeloproliferative neoplasm: Mayo-AGIMM study of 410 patients from two separate cohorts.

Ayalew Tefferi, Mythri Mudireddy, Francesco Mannelli, Kebede H Begna, Mrinal M Patnaik, Curtis A Hanson, Rhett P Ketterling, Naseema Gangat, Meera Yogarajah, Valerio De Stefano and 8 more

Open access · hybridAbstract read
In one paragraph

Article in Leukemia, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
76citing papers in PubMed, 2 pooled it
8.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

76 citing papers in PubMed, 2 syntheses or guidelines pooled it, 140 citations in OpenAlex.

  1. Pooled it
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  9. Article
  10. Targeting DESI2 as a Novel Therapeutic Strategy for JAK2-Mutant Leukemias.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  11. The global epidemiology of acute myeloid leukaemia.Nature reviews. Clinical oncology · 2026
    Review
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  13. Article
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  15. Article
  16. Article
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16 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 7 institutions in 2 countries.

Ayalew TefferiMayo Clinic, Rochester, MN, USA. tefferi.ayalew@mayo.edu.
Mythri MudireddyMayo Clinic, Rochester, MN, USA.
Francesco MannelliAGIMM (AIRC-Gruppo Italiano Malattie Mieloproliferative: Rome, Varese, Pavia, Bergamo, Florence, Italy.
Kebede H BegnaMayo Clinic, Rochester, MN, USA.
Mrinal M PatnaikMayo Clinic, Rochester, MN, USA.ORCID http://orcid.org/0000-0001-6998-662X
Curtis A HansonMayo Clinic, Rochester, MN, USA.
Rhett P KetterlingMayo Clinic, Rochester, MN, USA.
Naseema GangatMayo Clinic, Rochester, MN, USA.
Meera YogarajahBrody School of Medicine, East Carolina University, Greenville, NC, USA.
Valerio De StefanoAGIMM (AIRC-Gruppo Italiano Malattie Mieloproliferative: Rome, Varese, Pavia, Bergamo, Florence, Italy.
Francesco PassamontiAGIMM (AIRC-Gruppo Italiano Malattie Mieloproliferative: Rome, Varese, Pavia, Bergamo, Florence, Italy.
Vittorio RostiAGIMM (AIRC-Gruppo Italiano Malattie Mieloproliferative: Rome, Varese, Pavia, Bergamo, Florence, Italy.
Maria Chiara FinazziAGIMM (AIRC-Gruppo Italiano Malattie Mieloproliferative: Rome, Varese, Pavia, Bergamo, Florence, Italy.
Alessandro RambaldiAGIMM (AIRC-Gruppo Italiano Malattie Mieloproliferative: Rome, Varese, Pavia, Bergamo, Florence, Italy.
Alberto BosiAGIMM (AIRC-Gruppo Italiano Malattie Mieloproliferative: Rome, Varese, Pavia, Bergamo, Florence, Italy.
Paola GuglielmelliAGIMM (AIRC-Gruppo Italiano Malattie Mieloproliferative: Rome, Varese, Pavia, Bergamo, Florence, Italy.
Animesh PardananiMayo Clinic, Rochester, MN, USA.
Alessandro M VannucchiAGIMM (AIRC-Gruppo Italiano Malattie Mieloproliferative: Rome, Varese, Pavia, Bergamo, Florence, Italy.
Mayo Clinic in Arizona · USUniversity of Florence · ITOspedale Papa Giovanni XXIII · ITEast Carolina University · USFoundation Center · USUniversità Cattolica del Sacro Cuore · ITUniversity of Insubria · IT

Funding

ZESTRIL VS. VERAPAMIL IN THE TREATMENT OF HYPERTENSIONM01RR000585 · NCRR · MAYO CLINIC ROCHESTER · PI RIZZA, ROBERT A. · 1985 to 2006
$30.4M
Institutional Career Development CoreKL2TR002379 · NCATS · MAYO CLINIC ROCHESTER · PI NILUFER ERTEKIN-TANER · 2017 to 2026
$14.9M
NCATS NIH HHS KL2 TR002379NCRR NIH HHS M01 RR000585
6 · The paper itself

Abstract

A total of 410 patients with blast phase myeloproliferative neoplasm (MPN-BP) were retrospectively reviewed: 248 from the Mayo Clinic and 162 from Italy. Median survival was 3.6 months, with no improvement over the last 15 years. Multivariable analysis performed on the Mayo cohort identified high risk karyotype, platelet count < 100 × 10

Indexed as

Blast CrisisAdultAgedAged, 80 and overCohort StudiesFemaleHematopoietic Stem Cell TransplantationHumansItalyMaleMiddle AgedMyeloproliferative DisordersNeoplasmsRemission InductionRetrospective StudiesRisk Factors

Identifiers

PMID29459662
PMCPMC5940634
OpenAlexW2790425028

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.