Evidence map›Paper›PMID 29459656›Full record

ArticleSpinal cord2018

Electromyographic patterns of the rat hindlimb in response to muscle stretch after spinal cord injury.

Anastasia V Keller, Kathlene M Rees, Erik J Seibt, B Danni Wood, Abigail D Wade, Johnny Morehouse, Alice Shum-Siu, David S K Magnuson

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Spinal cord, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 25 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Anastasia V KellerDepartments of Physiology, University of Louisville, Louisville, USA.
Kathlene M ReesDepartments of Neurological Surgery, University of Louisville, Louisville, USA.
Erik J SeibtDepartments of Neurological Surgery, University of Louisville, Louisville, USA.
B Danni WoodDepartments of Neurological Surgery, University of Louisville, Louisville, USA.
Abigail D WadeDepartments of Neurological Surgery, University of Louisville, Louisville, USA.
Johnny MorehouseDepartments of Neurological Surgery, University of Louisville, Louisville, USA.
Alice Shum-SiuDepartments of Neurological Surgery, University of Louisville, Louisville, USA.
David S K MagnusonDepartments of Physiology, University of Louisville, Louisville, USA. dsmagn01@louisville.edu.ORCID http://orcid.org/0000-0003-3816-3676
University of Louisville · US

Funding

MECHANISMS OF PLASTICITY AND REPAIR AFTER SCIP30RR031159 · NCRR · UNIVERSITY OF LOUISVILLE · PI WHITTEMORE, SCOTT R · 2011 to 2011
$1.1M
Re-training locomotor circuitry in a rat model of spinal cord injuryR56NS052292 · NINDS · UNIVERSITY OF LOUISVILLE · PI MAGNUSON, DAVID SK · 2011 to 2011
$373k
NCRR NIH HHS P30 RR031159NINDS NIH HHS R56 NS052292
6 · The paper itself

Abstract

STUDY

designExperimental Study.

objectivesTo characterize the specific hindlimb electromyographic (EMG) patterns in response to muscle stretch and to measure the applied forces during stretching in the rat model of moderate SCI.

settingKentucky Spinal Cord Injury Research Center, Louisville, KY, USA.

methodsFemale Sprague Dawley rats (n = 4) were instrumented for telemetry-based EMG recording (right rectus femoris and biceps femoris) and received a moderate T10 spinal cord injury (SCI). The major hindlimb muscle groups were stretched using our clinically modeled protocol. The EMG responses were recorded biweekly for 8 weeks. The forces applied during stretching were measured using a custom-designed glove. Locomotor function was assessed using the BBB Open Field Locomotor Scale, 3D kinematics and gait analysis.

resultsThree main EMG patterns in response to stretch were identified: clonic-like, air-stepping, and spasms. Torques applied during stretching ranged from 0.4-8 N•cm, and with the exception of the quadriceps, did not change significantly over the weeks of stretching. Two stretching sessions a week did not result in a significant disruption to locomotor function.

conclusionsStretching evokes EMG patterns in rats similar to those reported in humans including clonus and spasms. The torques used during stretching are comparable, based on the ratio of torque to body weight, to the few previously published studies that measured the forces and/or torques applied by physical therapists when stretching patients. Future studies are warranted to fully explore the impact of muscle stretch on spinal cord function after injury. SPONSORSHIP: DoD, KSCHIRT, NIH.

Indexed as

ElectromyographyAnimalsBiomechanical PhenomenaDisease Models, AnimalFemaleGaitHindlimbMuscle, SkeletalMuscle Stretching ExercisesRats, Sprague-DawleySpasmSpinal Cord InjuriesThoracic Vertebrae

Identifiers

PMID29459656
PMCPMC5984666
OpenAlexW2791507791

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.