Evidence map›Paper›PMID 29459654›Full record

ArticleNature nanotechnology2018

Photoelectrochemical modulation of neuronal activity with free-standing coaxial silicon nanowires.

Ramya Parameswaran, João L Carvalho-de-Souza, Yuanwen Jiang, Michael J Burke, John F Zimmerman, Kelliann Koehler, Andrew W Phillips, Jaeseok Yi, Erin J Adams, Francisco Bezanilla and 1 more

Abstract read
In one paragraph

Article in Nature nanotechnology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 104 papers.

0numbers the graph read from it
0cells of the map it votes in
104citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

104 citing papers in PubMed.

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44 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Ramya ParameswaranMedical Scientist Training Program, University of Chicago, Chicago, IL, USA.
João L Carvalho-de-SouzaDepartment of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL, USA.
Yuanwen JiangDepartment of Chemistry, University of Chicago, Chicago, IL, USA.ORCID 0000-0002-2056-2639
Michael J BurkeDepartment of Chemistry, University of Chicago, Chicago, IL, USA.
John F ZimmermanDepartment of Chemistry, University of Chicago, Chicago, IL, USA.
Kelliann KoehlerDepartment of Chemistry, University of Chicago, Chicago, IL, USA.
Andrew W PhillipsDepartment of Chemistry, University of Chicago, Chicago, IL, USA.ORCID 0000-0001-6092-3083
Jaeseok YiDepartment of Chemistry, University of Chicago, Chicago, IL, USA.ORCID 0000-0002-0578-1059
Erin J AdamsDepartment of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL, USA.
Francisco BezanillaDepartment of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL, USA. fbezanilla@peds.bsd.uchicago.edu.
Bozhi TianDepartment of Chemistry, University of Chicago, Chicago, IL, USA. btian@uchicago.edu.

Funding

MEDICAL SCIENTIST TRAININGT32GM007281 · NIGMS · UNIVERSITY OF CHICAGO · PI CLARK, MARCUS RAMSAY · 1985 to 2022
$32.1M
The Electrophysiological Studies of Voltage Gated ChannelsR01GM030376 · NIGMS · UNIVERSITY OF CHICAGO · PI BEZANILLA, FRANCISCO J · 1985 to 2025
$9.1M
Graduate Program in Biophysical Sciences at the University of Chicago - Renewal 0T32EB009412 · NIBIB · UNIVERSITY OF CHICAGO · PI ENGEL, GREGORY S, SOSNICK, TOBIN R · 2009 to 2023
$4.9M
Predoctoral Training Program in Chemistry & BiologyT32GM008720 · NIGMS · UNIVERSITY OF CHICAGO · PI PICCIRILLI, JOSEPH ANTHONY · 1999 to 2020
$4.7M
ELECTROPHYSIOLOGICAL STUDIES OF VOLTAGE GATED CHANNELSR37GM030376 · NIGMS · UNIVERSITY OF CHICAGO · PI BEZANILLA, FRANCISCO J · 1999 to 2008
$3.7M
Silicon-based Injectable Micro-gels for Non-genetic and Wireless Modulation of Neurons, Cardiomyocytes and Neuromuscular SystemDP2NS101488 · NINDS · UNIVERSITY OF CHICAGO · PI TIAN, BOZHI · 2016 to 2016
$2.4M
Silicon nanowires for probing effects of membrane voltage on the TCR-CD3 complexF30AI138156 · NIAID · UNIVERSITY OF CHICAGO · PI PARAMESWARAN, RAMYA · 2017 to 2018
$99k
NIAID NIH HHS F30 AI138156NIBIB NIH HHS T32 EB009412NIGMS NIH HHS R01 GM030376NIGMS NIH HHS R37 GM030376NIGMS NIH HHS T32 GM007281NIGMS NIH HHS T32 GM008720NINDS NIH HHS DP2 NS101488
6 · The paper itself

Abstract

Optical methods for modulating cellular behaviour are promising for both fundamental and clinical applications. However, most available methods are either mechanically invasive, require genetic manipulation of target cells or cannot provide subcellular specificity. Here, we address all these issues by showing optical neuromodulation with free-standing coaxial p-type/intrinsic/n-type silicon nanowires. We reveal the presence of atomic gold on the nanowire surfaces, likely due to gold diffusion during the material growth. To evaluate how surface gold impacts the photoelectrochemical properties of single nanowires, we used modified quartz pipettes from a patch clamp and recorded sustained cathodic photocurrents from single nanowires. We show that these currents can elicit action potentials in primary rat dorsal root ganglion neurons through a primarily atomic gold-enhanced photoelectrochemical process.

Indexed as

Action PotentialsAnimalsCells, CulturedElectrochemical TechniquesGanglia, SpinalGoldLightNanowiresNeuronsPhotochemical ProcessesRatsSiliconGoldSilicon

Identifiers

PMID29459654
PMCPMC6029690

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.