ArticlePhysics in medicine and biology2018
A dual-mode hemispherical sparse array for 3D passive acoustic mapping and skull localization within a clinical MRI guided focused ultrasound device.
Article in Physics in medicine and biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 41 citations in OpenAlex.
- Three-dimensional passive acoustic mapping of high intensity focused ultrasound fields using sparse synthetic apertures from rotated one-dimensional linear arrays.Scientific reports · 2026Article
- Overview of Therapeutic Ultrasound Applications and Safety Considerations: 2024 Update.Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2025Review
- Volumetric Passive Acoustic Mapping and Cavitation Detection of Nanobubbles under Low-Frequency Insonation.ACS materials Au · 2025Article
- CMUT as a Transmitter for Microbubble-Assisted Blood-Brain Barrier Opening.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2024Article
- Three-dimensional super resolution ultrasound imaging with a multi-frequency hemispherical phased array.Medical physics · 2023Article
- Cavitation Feedback Control of Focused Ultrasound Blood-Brain Barrier Opening for Drug Delivery in Patients with Parkinson's Disease.Pharmaceutics · 2022Article
- Two-step aberration correction: application to transcranial histotripsy.Physics in medicine and biology · 2022Article
- An Ultrasound-Guided Hemispherical Phased Array for Microbubble-Mediated Ultrasound Therapy.IEEE transactions on bio-medical engineering · 2022Article
- Emerging Therapeutic Strategies for Brain Tumors.Neuromolecular medicine · 2022Review
- Experimental Demonstration of Trans-Skull Volumetric Passive Acoustic Mapping With the Heterogeneous Angular Spectrum Approach.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2022Article
- Towards controlled drug delivery in brain tumors with microbubble-enhanced focused ultrasound.Advanced drug delivery reviews · 2022Review
- A theranostic 3D ultrasound imaging system for high resolution image-guided therapy.Theranostics · 2022Article
- Therapeutic Agent Delivery Across the Blood-Brain Barrier Using Focused Ultrasound.Annual review of biomedical engineering · 2021Review
- Passive Cavitation Mapping by Cavitation Source Localization From Aperture-Domain Signals-Part I: Theory and Validation Through Simulations.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2021Article
- Safety Review and Perspectives of Transcranial Focused Ultrasound Brain Stimulation.Brain & NeuroRehabilitation · 2021Review
- Blood-brain barrier opening with low intensity pulsed ultrasound for immune modulation and immune therapeutic delivery to CNS tumors.Journal of neuro-oncology · 2021Review
- Ultrasound-Responsive Cavitation Nuclei for Therapy and Drug Delivery.Ultrasound in medicine & biology · 2020Review
- Focused Ultrasound for Noninvasive, Focal Pharmacologic Neurointervention.Frontiers in neuroscience · 2020Review
- Ultrafast three-dimensional microbubble imagingTheranostics · 2020Article
- Advances in acoustic monitoring and control of focused ultrasound-mediated increases in blood-brain barrier permeability.The British journal of radiology · 2019Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Previous work has demonstrated that passive acoustic imaging may be used alongside MRI for monitoring of focused ultrasound therapy. However, past implementations have generally made use of either linear arrays originally designed for diagnostic imaging or custom narrowband arrays specific to in-house therapeutic transducer designs, neither of which is fully compatible with clinical MR-guided focused ultrasound (MRgFUS) devices. Here we have designed an array which is suitable for use within an FDA-approved MR-guided transcranial focused ultrasound device, within the bore of a 3 Tesla clinical MRI scanner. The array is constructed from 5 × 0.4 mm piezoceramic disc elements arranged in pseudorandom fashion on a low-profile laser-cut acrylic frame designed to fit between the therapeutic elements of a 230 kHz InSightec ExAblate 4000 transducer. By exploiting thickness and radial resonance modes of the piezo discs the array is capable of both B-mode imaging at 5 MHz for skull localization, as well as passive reception at the second harmonic of the therapy array for detection of cavitation and 3D passive acoustic imaging. In active mode, the array was able to perform B-mode imaging of a human skull, showing the outer skull surface with good qualitative agreement with MR imaging. Extension to 3D showed the array was able to locate the skull within ±2 mm/2° of reference points derived from MRI, which could potentially allow registration of a patient to the therapy system without the expense of real-time MRI. In passive mode, the array was able to resolve a point source in 3D within a ±10 mm region about each axis from the focus, detect cavitation (SNR ~ 12 dB) at burst lengths from 10 cycles to continuous wave, and produce 3D acoustic maps in a flow phantom. Finally, the array was used to detect and map cavitation associated with microbubble activity in the brain in nonhuman primates.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.