Trial reportCirculation2018
Sex Difference in Patients With Ischemic Heart Failure Undergoing Surgical Revascularization: Results From the STICH Trial (Surgical Treatment for Ischemic Heart Failure).
Trial report in Circulation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00023595 (Surgical Treatment for Ischemic Heart Failure), which is not on this map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Surgical Treatment for Ischemic Heart Failure (STICH)
Who cites it
18 citing papers in PubMed, 42 citations in OpenAlex.
- Differences in NT-proBNP Response and Prognosis in Men and Women With Heart Failure With Reduced Ejection Fraction.Journal of the American Heart Association · 2021Trial
- Sex Differences in Long-term Outcomes Following Coronary Artery Bypass Grafting: A Nationwide Population-Based Propensity Score-Matched Cohort Study.Journal of Korean medical science · 2026Article
- Sex-related differences in long-term mortality after coronary artery bypass graft surgery: A systematic review and meta-analysis.International journal of cardiology. Cardiovascular risk and prevention · 2026Article
- Long-term outcomes of women compared to men after off-pump coronary artery bypass grafting-a propensity-matched analysis.Indian journal of thoracic and cardiovascular surgery · 2025Article
- Sex differences in the impact of frailty on patients with heart failure: A retrospective cohort study.ESC heart failure · 2024Article
- Gender Effect on Clinical Profiles, Pharmacological Treatments and Prognosis in Patients Hospitalized for Heart Failure.Journal of clinical medicine · 2024Review
- Impact of gender on mid-term prognosis of patients undergoing coronary artery bypass grafting.PloS one · 2023Observational
- BMI disparities in coronary artery bypass grafting outcomes: A single center Society of Thoracic Surgeons (STS) database analysis.Surgery in practice and science · 2022Article
- Time-Dependent Impact of Sex on the Long-Term Outcomes After Left Main Revascularization.Journal of the American Heart Association · 2022Article
- Long-term survival of female versus male patients after coronary artery bypass grafting.PloS one · 2022Article
- Comparable outcomes between genders in patients undergoing surgical ventricular reconstruction for ischaemic heart failure.ESC heart failure · 2021Article
- Co-morbidities and co-medications as confounders of cardioprotection-Does it matter in the clinical setting?British journal of pharmacology · 2020Review
- Sex Differences in Cardiovascular Disease and Cognitive Impairment: Another Health Disparity for Women?Journal of the American Heart Association · 2019Review
- Both sexes should be treated equally: sex difference in patients with ischemic heart failure undergoing surgical revascularization.Journal of thoracic disease · 2018Article
- Sex and mortality associated with coronary artery bypass graft.Journal of thoracic disease · 2018Article
- Female gender and left ventricular dysfunction in myocardial surgical revascularization: the strange couple.Journal of thoracic disease · 2018Article
- Gender and surgical revascularization: there is a light at the end of the tunnel?Journal of thoracic disease · 2018Article
- Differential metabolomics analysis allows characterization of diversity of metabolite networks between males and females.PloS one · 2018Article
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Authors and funding
19 authors at 16 institutions in 9 countries.
Funding
Abstract
backgroundFemale sex is conventionally considered a risk factor for coronary artery bypass grafting (CABG) and has been included as a poor prognostic factor in multiple cardiac operative risk evaluation scores. We aimed to investigate the association of sex and the long-term benefit of CABG in patients with ischemic left ventricular dysfunction enrolled in the prospective STICH trial (Surgical Treatment for Ischemic Heart Failure Study).
methodsThe STICH trial randomized 1212 patients (148 [12%] women and 1064 [88%] men) with coronary artery disease and left ventricular ejection fraction ≤35% to CABG+medical therapy (MED) versus MED alone. Long-term (10-year) outcomes with each treatment were compared according to sex.
resultsAt baseline, women were older (63.4 versus 59.3 years;
conclusionsSex is not associated with the effect of CABG+MED versus MED on all-cause mortality, cardiovascular mortality, the composite of death or cardiovascular hospitalization, or surgical deaths in patients with ischemic left ventricular dysfunction. Thus, sex should not influence treatment decisions about CABG in these patients. CLINICAL
trial registrationURL: https://www.clinicaltrials.gov. Unique identifier: NCT00023595.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.