Evidence map›Paper›PMID 29459438›Full record

ArticleThe EMBO journal2018

Non-cell-autonomous function of DR6 in Schwann cell proliferation.

Alessio Colombo, Hung-En Hsia, Mengzhe Wang, Peer-Hendrik Kuhn, Monika S Brill, Paolo Canevazzi, Regina Feederle, Carla Taveggia, Thomas Misgeld, Stefan F Lichtenthaler

Open access · bronzeAbstract read
In one paragraph

Article in The EMBO journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.3field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 22 citations in OpenAlex.

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  5. The pseudoprotease iRhom1 controls ectodomain shedding of membrane proteins in the nervous system.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Alessio ColomboGerman Center for Neurodegenerative Diseases (DZNE), Munich, Germany.
Hung-En HsiaGerman Center for Neurodegenerative Diseases (DZNE), Munich, Germany.ORCID 0000-0002-6691-9808
Mengzhe WangInstitute of Neuronal Cell Biology, Technical University of Munich, Munich, Germany.
Peer-Hendrik KuhnNeuroproteomics, Klinikum rechts der Isar, and Institute for Advanced Study, Technical University Munich, Munich, Germany.
Monika S BrillInstitute of Neuronal Cell Biology, Technical University of Munich, Munich, Germany.
Paolo CanevazziDivision of Neuroscience, INSPE at San Raffaele Scientific Institute, Milan, Italy.
Regina FeederleGerman Center for Neurodegenerative Diseases (DZNE), Munich, Germany.ORCID 0000-0002-3981-367X
Carla TaveggiaDivision of Neuroscience, INSPE at San Raffaele Scientific Institute, Milan, Italy.
Thomas MisgeldGerman Center for Neurodegenerative Diseases (DZNE), Munich, Germany.ORCID 0000-0001-9875-6794
Stefan F LichtenthalerGerman Center for Neurodegenerative Diseases (DZNE), Munich, Germany stefan.lichtenthaler@dzne.de.ORCID 0000-0003-2211-2575
German Center for Neurodegenerative Diseases · DESan Raffaele University of Rome · ITTechnical University of Munich · DECenter for Integrated Protein Science Munich · DETUM Klinikum · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Death receptor 6 (DR6) is an orphan member of the TNF receptor superfamily and controls cell death and differentiation in a cell-autonomous manner in different cell types. Here, we report an additional non-cell-autonomous function for DR6 in the peripheral nervous system (PNS). DR6-knockout (DR6 KO) mice showed precocious myelination in the PNS Using an

Indexed as

Cell ProliferationADAM10 ProteinAmyloid Precursor Protein SecretasesAnimalsCell DeathCell LineCytoplasmDeath DomainDisintegrinsFemaleHEK293 CellsHumansHybridomasMaleMembrane ProteinsMetalloproteasesADAM10 ProteinAdam10 protein, mouseAmyloid Precursor Protein SecretasesDisintegrinsMembrane ProteinsMetalloproteasesReceptors, Tumor Necrosis FactorTnfrsf21 protein, mouseADAM10DR6myelinSchwann cellshedding

Identifiers

PMID29459438
PMCPMC5881626
OpenAlexW2789137287

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.