ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2018
Rescue of Learning and Memory Deficits in the Human Nonsyndromic Intellectual Disability Cereblon Knock-Out Mouse Model by Targeting the AMP-Activated Protein Kinase-mTORC1 Translational Pathway.
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Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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27citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
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27 citing papers in PubMed, 39 citations in OpenAlex.
- Review
- Cereblon-related mild intellectual disability disrupts response inhibition and uniformity of group-individual strategies.Frontiers in neuroscience · 2026Article
- A method for the detection and enrichment of endogenous cereblon substrates.Cell chemical biology · 2025Article
- Comprehensive behavioral characterization and impaired hippocampal synaptic transmission in R1117X Shank3 mutant mice.Translational psychiatry · 2025Article
- A method for the detection and enrichment of endogenous cereblon substrates.bioRxiv : the preprint server for biology · 2025Article
- Cerebellar output neurons can impair non-motor behaviors by altering development of extracerebellar connectivity.Nature communications · 2025Article
- Enhanced homeostatic sleep response and decreased neurodegenerative proteins in cereblon knock-out mice.Communications biology · 2024Article
- Cerebellar output neurons impair non-motor behaviors by altering development of extracerebellar connectivity.bioRxiv : the preprint server for biology · 2024Article
- The CBEMBO molecular medicine · 2024Article
- N-acetylcysteine improves autism-like behavior by recovering autophagic deficiency and decreasing Notch-1/Hes-1 pathway activity.Experimental biology and medicine (Maywood, N.J.) · 2023Article
- Esco2 and cohesin regulate CRL4 ubiquitin ligaseCell cycle (Georgetown, Tex.) · 2022Article
- Cereblon Regulates the Proteotoxicity of Tau by Tuning the Chaperone Activity of DNAJA1.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Dopamine D1R-neuron cacna1c deficiency: a new model of extinction therapy-resistant post-traumatic stress.Molecular psychiatry · 2021Article
- A mouse model of Bardet-Biedl Syndrome has impaired fear memory, which is rescued by lithium treatment.PLoS genetics · 2021Article
- Bassoon inhibits proteasome activity via interaction with PSMB4.Cellular and molecular life sciences : CMLS · 2021Article
- Post-Translational Modifications of the Energy Guardian AMP-Activated Protein Kinase.International journal of molecular sciences · 2021Review
- Comparative Genomics Identifies Putative Interspecies Mechanisms Underlying Crbn-Sall4-Linked Thalidomide Embryopathy.Frontiers in genetics · 2021Article
- Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine.Frontiers in cell and developmental biology · 2021Review
- Role of mTOR-Regulated Autophagy in Synaptic Plasticity Related Proteins Downregulation and the Reference Memory Deficits Induced by Anesthesia/Surgery in Aged Mice.Frontiers in aging neuroscience · 2021Article
- Cocaine- and stress-primed reinstatement of drug-associated memories elicit differential behavioral and frontostriatal circuit activity patterns via recruitment of L-type CaMolecular psychiatry · 2020Article
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Authors and funding
13 authors at 5 institutions in 1 country.
Charlotte C BavleyPediatric Neurology, Department of Pediatrics.ORCID 0000-0001-7273-7392
Richard C RicePediatric Neurology, Department of Pediatrics.ORCID 0000-0002-8636-5697
Delaney K FischerPediatric Neurology, Department of Pediatrics.
Amanda K FakiraDepartment of Anesthesiology, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York 10032.ORCID 0000-0001-7626-3833
Maureen ByrnePediatric Neurology, Department of Pediatrics.
Maria KosovskyPediatric Neurology, Department of Pediatrics.
Bryant K RizzoPediatric Neurology, Department of Pediatrics.
Dolores Del PreteDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York 10461.
Armin AlaediniWeill Cornell Autism Research Program, Weill Cornell Medical College, Cornell University, New York, NY 10065.ORCID 0000-0002-5776-8585
Jose A MorónDepartment of Anesthesiology, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York 10032.
Joseph J HigginsPediatric Neurology, Department of Pediatrics.
Luciano D'AdamioDepartment of Pharmacology, Physiology and Neuroscience, New Jersey Medical School, Rutgers University, Newark, NJ 07103.
Anjali M RajadhyakshaPediatric Neurology, Department of Pediatrics, amr2011@med.cornell.edu.
Cornell University · USColumbia University · USPediatrics and Genetics · USAlbert Einstein College of Medicine · USRutgers, The State University of New Jersey · US
Funding
Mechanisms of APP and APLP2 function at synapsesR01AG052286 · NIA · RBHS-NEW JERSEY MEDICAL SCHOOL · PI D'ADAMIO, LUCIANO · 2016 to 2020
$3.5MDissecting circuits mediating pain-induced alterations in motivated behaviorR01DA041781 · NIDA · WASHINGTON UNIVERSITY · PI MORON-CONCEPCION, JOSE A · 2017 to 2021
$2.3MThe Role of Cav1.2 L-type Ca2+ Channels in Cocaine-Induced ReinstatementR01DA029122 · NIDA · WEILL MEDICAL COLL OF CORNELL UNIV · PI RAJADHYAKSHA, ANJALI M · 2012 to 2016
$2.1MRole of SK2 channels in morphine dependenceR01DA042499 · NIDA · WASHINGTON UNIVERSITY · PI MORON-CONCEPCION, JOSE A · 2017 to 2021
$1.9MGenetic and Environmental Influences on AddictionT32DA039080 · NIDA · WEILL MEDICAL COLL OF CORNELL UNIV · PI Teresa A Milner · 2017 to 2026
$1.4MIn vivo imaging of dynamic structural plasticity driving morphine conditioned place preferenceR21DA042581 · NIDA · WASHINGTON UNIVERSITY · PI HAN, EDWARD BING, MORON-CONCEPCION, JOSE A · 2016 to 2017
$381kUSING TRANSGENIC MICE TO EXAMINE THE ROLE OF CNIH3 VARIANTS IN OPIOID DEPENDENCER21DA041883 · NIDA · WASHINGTON UNIVERSITY · PI DOUGHERTY, JOSEPH D, MORON-CONCEPCION, JOSE A · 2016 to 2017
$379kNIA NIH HHS R01 AG052286NIDA NIH HHS R01 DA029122NIDA NIH HHS R01 DA041781NIDA NIH HHS R01 DA042499NIDA NIH HHS R21 DA041883NIDA NIH HHS R21 DA042581NIDA NIH HHS T32 DA039080
Abstract
A homozygous nonsense mutation in the cereblon (
Indexed as
Adaptor Proteins, Signal TransducingAnimalsCA1 Region, HippocampalExcitatory Postsynaptic PotentialsHippocampusIntellectual DisabilityLearning DisabilitiesLong-Term PotentiationMaleMechanistic Target of Rapamycin Complex 1Memory DisordersMiceMice, Inbred C57BLMice, KnockoutMitogen-Activated Protein KinasesNerve Tissue ProteinsAdaptor Proteins, Signal TransducingCrbn protein, mouseMechanistic Target of Rapamycin Complex 1Mitogen-Activated Protein KinasesNerve Tissue ProteinsProtein Kinase InhibitorsAMPKcereblonexcitatoryglutamatergicintellectual disabilitymTOR
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.