Evidence map›Paper›PMID 29459239›Full record

ReviewThe Canadian journal of cardiology2018

Diabetes, Hypertension, and Cardiovascular Disease: Clinical Insights and Vascular Mechanisms.

John R Petrie, Tomasz J Guzik, Rhian M Touyz

Registry-linked trialAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in The Canadian journal of cardiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07432126 (Community Health Workers Led Integrated Management of Hypertension and Diabetes in Nepal), which is not on this map. Cited by 924 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
924citing papers in PubMed, 11 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07432126 narecruitingnot on this mapstarted 2025, after this paper: background citation

Community Health Workers Led Integrated Management of Hypertension and Diabetes in Nepal

TypeinterventionalSponsorKathmandu University School of Medical SciencesRan2025 to 2027Enrolled398ConditionsHypertension (HTN), Diabetes (DM)ArmsIntegrated management of hypertension and diabetes using group care approach
3 · Its place in the literature

Who cites it

924 citing papers in PubMed, 11 syntheses or guidelines pooled it.

  1. Blood pressure targets for hypertension in people with diabetes mellitus.The Cochrane database of systematic reviews · 2026
    Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Does retinal vascular occlusion increase the risk of dementia? A pioneering systematic review and meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
    Pooled it
  7. Pooled it
  8. Effects ofNutrients · 2025
    Pooled it
  9. Pooled it
  10. Pooled it
  11. Pooled it
  12. Trial
  13. Trial
  14. Trial
  15. Review
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article

864 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

John R PetrieInstitute of Cardiovascular and Medical Sciences, University of Glasgow, United Kingdom.
Tomasz J GuzikInstitute of Cardiovascular and Medical Sciences, University of Glasgow, United Kingdom.
Rhian M TouyzInstitute of Cardiovascular and Medical Sciences, University of Glasgow, United Kingdom. Electronic address: rhian.touyz@glasgow.ac.uk.

Funding

British Heart Foundation RE/13/5/30177British Heart Foundation RG/13/7/30099Wellcome Trust
6 · The paper itself

Abstract

Hypertension and type 2 diabetes are common comorbidities. Hypertension is twice as frequent in patients with diabetes compared with those who do not have diabetes. Moreover, patients with hypertension often exhibit insulin resistance and are at greater risk of diabetes developing than are normotensive individuals. The major cause of morbidity and mortality in diabetes is cardiovascular disease, which is exacerbated by hypertension. Accordingly, diabetes and hypertension are closely interlinked because of similar risk factors, such as endothelial dysfunction, vascular inflammation, arterial remodelling, atherosclerosis, dyslipidemia, and obesity. There is also substantial overlap in the cardiovascular complications of diabetes and hypertension related primarily to microvascular and macrovascular disease. Common mechanisms, such as upregulation of the renin-angiotensin-aldosterone system, oxidative stress, inflammation, and activation of the immune system likely contribute to the close relationship between diabetes and hypertension. In this article we discuss diabetes and hypertension as comorbidities and discuss the pathophysiological features of vascular complications associated with these conditions. We also highlight some vascular mechanisms that predispose to both conditions, focusing on advanced glycation end products, oxidative stress, inflammation, the immune system, and microRNAs. Finally, we provide some insights into current therapies targeting diabetes and cardiovascular complications and introduce some new agents that may have vasoprotective therapeutic potential in diabetes.

Indexed as

Blood VesselsDiabetes Mellitus, Type 2HypertensionDisease ManagementHumansInflammationMicroRNAsOxidative StressMicroRNAs

Identifiers

PMID29459239
PMCPMC5953551

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.