Evidence map›Paper›PMID 29459206›Full record

ArticleBioorganic & medicinal chemistry letters2018

Structure-based design and biological evaluation of inhibitors of the pseudomonas aeruginosa heme oxygenase (pa-HemO).

Dongdong Liang, Elizabeth Robinson, Kellie Hom, Wenbo Yu, Nam Nguyen, Yue Li, Qianshou Zong, Angela Wilks, Fengtian Xue

Abstract read
In one paragraph

Article in Bioorganic & medicinal chemistry letters, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Review
  3. Computer-Aided Drug Design: An Update.Methods in molecular biology (Clifton, N.J.) · 2023
    Article
  4. Article
  5. Article
  6. Metallotherapeutics development in the age of iron-clad bacteria.Metallomics : integrated biometal science · 2020
    Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Dongdong LiangDepartment of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, MD 21201, United States.
Elizabeth RobinsonDepartment of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, MD 21201, United States.
Kellie HomDepartment of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, MD 21201, United States.
Wenbo YuDepartment of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, MD 21201, United States.
Nam NguyenDepartment of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, MD 21201, United States.
Yue LiDepartment of Chemistry and Biochemistry, University of Maryland College Park, College Park 20740, United States.
Qianshou ZongCollege of Biological and Chemical Sciences and Engineering, Jiaxing University, Jiaxing City, Zhejiang 314001, People's Republic of China.
Angela WilksDepartment of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, MD 21201, United States. Electronic address: awilks@rx.umaryland.edu.
Fengtian XueDepartment of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, MD 21201, United States. Electronic address: fxue@rx.umaryland.edu.

Funding

EXPAND PARTICIPATION BY MINORITIES IN BIOMEDICAL SCIENCER25GM055036 · NIGMS · UNIVERSITY OF MARYLAND BALTIMORE COUNTY · PI SUMMERS, MICHAEL FINLEY · 1996 to 2021
$16.9M
Graduate Training at The Chemistry Biology InterfaceT32GM066706 · NIGMS · UNIVERSITY OF MARYLAND BALTIMORE COUNTY · PI SELEY-RADTKE, KATHERINE L, SMITH, AARON T · 2004 to 2023
$3.3M
Heme utilization and homeostasis in Pseudomonas aeruginosaR01AI102883 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI WILKS, ANGELA · 2013 to 2017
$2.0M
NIAID NIH HHS R01 AI102883NIGMS NIH HHS R25 GM055036NIGMS NIH HHS T32 GM066706
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Drug DesignAnti-Bacterial AgentsCatalytic DomainDose-Response Relationship, DrugEnzyme InhibitorsHeme Oxygenase (Decyclizing)Molecular StructurePseudomonas aeruginosaStructure-Activity RelationshipAnti-Bacterial AgentsEnzyme InhibitorsHeme Oxygenase (Decyclizing)

Identifiers

PMID29459206
PMCPMC5851869

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.