Evidence map›Paper›PMID 29459033›Full record

ReviewAdvances in protein chemistry and structural biology2018

Defining Pharmacological Targets by Analysis of Virus-Host Protein Interactions.

Manuel Llano, Mario A Peña-Hernandez

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Advances in protein chemistry and structural biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.1field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Identification of Virus-Host Protein Interactions Via Proteomic Techniques.Methods in molecular biology (Clifton, N.J.) · 2025
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 2 countries.

Manuel LlanoUniversity of Texas at El Paso, El Paso, TX, United States. Electronic address: mllano@utep.edu.
Mario A Peña-HernandezUniversity of Texas at El Paso, El Paso, TX, United States; Laboratorio de Inmunología y Virología, Facultad de Ciencias Biológicas, Universidad Autónoma de Nuevo León, San Nicolas de los Garza, Mexico.
The University of Texas at El Paso · US

Funding

Role of PARP-1 in HIV-1 latent infectionSC1GM115240 · NIGMS · UNIVERSITY OF TEXAS EL PASO · PI LLANO, MANUEL · 2016 to 2019
$1.5M
NIGMS NIH HHS SC1 GM115240
6 · The paper itself

Abstract

Viruses are obligate parasites that depend on cellular factors for replication. Pharmacological inhibition of essential viral proteins, mostly enzymes, is an effective therapeutic alternative in the absence of effective vaccines. However, this strategy commonly encounters drug resistance mechanisms that allow these pathogens to evade control. Due to the dependency on host factors for viral replication, pharmacological disruption of the host-pathogen protein-protein interactions (PPIs) is an important therapeutic alternative to block viral replication. In this review we discuss salient aspects of PPIs implicated in viral replication and advances in the development of small molecules that inhibit viral replication through antagonism of these interactions.

Indexed as

Antiviral AgentsHost Microbial InteractionsHumansSmall Molecule LibrariesViral ProteinsVirusesAntiviral AgentsSmall Molecule LibrariesViral ProteinsCellular cofactorsProtein complexesProtein–protein interactionSmall organic moleculesViral replicationVirusesVirus–host interactomeVirus–host protein interactions

Identifiers

PMID29459033
PMCPMC6322211
OpenAlexW2778038613

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.