ArticleTrends in cancer2018
The Sympathetic Nervous System Drives Tumor Angiogenesis.
Article in Trends in cancer, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 49 citations in OpenAlex.
- Temporal effects of sympathetic denervation on aortic remodeling and rupture in experimental abdominal aortic aneurysm.American journal of physiology. Heart and circulatory physiology · 2025Article
- Sympathetic nervous system in tumor progression and metabolic regulation: mechanisms and clinical potential.Journal of translational medicine · 2025Review
- Review
- Social Genomic Determinants of Health: Understanding the Molecular Pathways by Which Neighborhood Disadvantage Affects Cancer Outcomes.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2024Review
- Targeting the tumour vasculature: from vessel destruction to promotion.Nature reviews. Cancer · 2024Review
- ZIP Code to Genomic Code: Neighborhood Disadvantage, Aggressive Breast Cancer Biology, and Breast Cancer Outcomes.Annals of surgery · 2024Article
- Article
- Characterization of a phenol-based model for denervation of the abdominal aorta and its implications for aortic remodeling.JVS-vascular science · 2024Article
- Effects of surgical trauma and intraoperative blood loss on tumour progression.Frontiers in oncology · 2024Review
- Overactivation of Norepinephrine-β2-Adrenergic Receptor Axis Promotes Corneal Neovascularization.Investigative ophthalmology & visual science · 2023Article
- Magnetic Nanomaterials Mediate Electromagnetic Stimulations of Nerves for Applications in Stem Cell and Cancer Treatments.Journal of functional biomaterials · 2023Review
- Investigating the crosstalk between chronic stress and immune cells: implications for enhanced cancer therapy.Frontiers in neuroscience · 2023Review
- Emerging role of substance and energy metabolism associated with neuroendocrine regulation in tumor cells.Frontiers in endocrinology · 2023Review
- Article
- An Overview of the Molecular Cues and Their Intracellular Signaling Shared by Cancer and the Nervous System: From Neurotransmitters to Synaptic Proteins, Anatomy of an All-Inclusive Cooperation.International journal of molecular sciences · 2022Review
- Effect of chronic stress on tumorigenesis and development.Cellular and molecular life sciences : CMLS · 2022Review
- Review
- The Nervous System Contributes to the Tumorigenesis and Progression of Human Digestive Tract Cancer.Journal of immunology research · 2022Review
- Review
- Chemogenetic modulation of sensory neurons reveals their regulating role in melanoma progression.Acta neuropathologica communications · 2021Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neurobiology is increasingly contributing to cancer research. Recent work indicates that noradrenaline released by sympathetic adrenergic nerves in prostate cancer can stimulate β-adrenoceptors in endothelial cells. This leads to the alteration of endothelial cell metabolism toward the inhibition of oxidative phosphorylation and the induction of an angiogenic switch that fuels cancer progression. These findings suggest that the sympathetic nervous system is a higher-level control of tumor angiogenesis that could be targeted in clinical oncology.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.