Evidence map›Paper›PMID 29458842›Full record

Trial reportNeurobiology of aging2018

Cognitive response to fish oil, blueberry, and combined supplementation in older adults with subjective cognitive impairment.

Robert K McNamara, Wilhelmina Kalt, Marcelle D Shidler, Jane McDonald, Suzanne S Summer, Amanda L Stein, Amanda N Stover, Robert Krikorian

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Neurobiology of aging, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers, 12 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
67citing papers in PubMed, 12 pooled it
5.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

67 citing papers in PubMed, 12 syntheses or guidelines pooled it, 134 citations in OpenAlex.

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  6. Biomarkers of Berry Intake: Systematic Review Update.Journal of agricultural and food chemistry · 2023
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7 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Robert K McNamaraDepartment of Psychiatry and Behavioral Neuroscience, University of Cincinnati Academic Health Center, Cincinnati, OH, USA.
Wilhelmina KaltAgriculture and Agri-Food Canada, Kentville Research and Development Centre, Kentville, Nova Scotia, Canada.
Marcelle D ShidlerDepartment of Psychiatry and Behavioral Neuroscience, University of Cincinnati Academic Health Center, Cincinnati, OH, USA.
Jane McDonaldAgriculture and Agri-Food Canada, Kentville Research and Development Centre, Kentville, Nova Scotia, Canada.
Suzanne S SummerClinical Translational Research Center, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Amanda L SteinDepartment of Psychiatry and Behavioral Neuroscience, University of Cincinnati Academic Health Center, Cincinnati, OH, USA.
Amanda N StoverDepartment of Psychiatry and Behavioral Neuroscience, University of Cincinnati Academic Health Center, Cincinnati, OH, USA.
Robert KrikorianDepartment of Psychiatry and Behavioral Neuroscience, University of Cincinnati Academic Health Center, Cincinnati, OH, USA. Electronic address: robert.krikorian@uc.edu.
University of Cincinnati Medical Center · USAgriculture and Agri-Food Canada · CACincinnati Children's Hospital Medical Center · USKentville Research and Development Centre

Funding

Omega-3 and Blueberry Supplmentation in Age-Related Cognitive DeclineR01AG034617 · NIA · UNIVERSITY OF CINCINNATI · PI KRIKORIAN, ROBERT · 2009 to 2011
$1.3M
NIA NIH HHS R01 AG034617
6 · The paper itself

Abstract

Given evidence that eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and anthocyanin-rich blueberries provide neurocognitive benefit, we investigated long-term supplementation in older adults with cognitive complaints. In a 24-week randomized, double-blind, placebo-controlled trial, elderly men and women received daily fish oil (FO) or blueberry (BB) or both. Diet records confirmed that participants reduced background consumption of EPA, DHA, and anthocyanins as prescribed. Erythrocyte EPA + DHA composition increased in the FO groups (p = 0.0001). Total urinary anthocyanins did not differ between the groups after supplementation but glycoside and native (food) forms increased only in the BB-supplemented groups. The FO (p = 0.03) and BB (p = 0.05) groups reported fewer cognitive symptoms, and the BB group showed improved memory discrimination (p = 0.04), indicating that supplementation improved cognition. Cognitive benefit in the BB group was associated with the presence of urinary anthocyanins reflecting recent BB intake but not with anthocyanin metabolites. However, combined FO + BB treatment was not associated with cognitive enhancement as expected.

Indexed as

Blueberry PlantsCognitionDietary SupplementsAgedAnthocyaninsCognitive DysfunctionDocosahexaenoic AcidsDouble-Blind MethodEicosapentaenoic AcidFemaleFish OilsGlycosidesHumansMaleMemoryMiddle AgedAnthocyaninsDocosahexaenoic AcidsEicosapentaenoic AcidFish OilsGlycosidesAgingAnthocyaninsBlueberriesDementiaMemoryOmega-3 fatty acids

Identifiers

PMID29458842
PMCPMC5822748
OpenAlexW2773834101

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.