ArticleEpidemiology and infection2018
Epidemiology and control measures of an OXA-48-producing Enterobacteriaceae hospital-wide oligoclonal outbreak.
Article in Epidemiology and infection, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- A decade of epidemiology and incidence of carbapenemase-producing bacteria in a tertiary hospital in southern Europe.Infection prevention in practice · 2025Article
- Intestinal loads of extended-spectrum beta-lactamase and Carbapenemase genes in critically ill pediatric patients.Frontiers in cellular and infection microbiology · 2023Article
- Dissemination of a single ST11 clone of OXA-48-producingMicrobial genomics · 2022Article
- Whole-Genome Sequencing Elucidates the Epidemiology of Multidrug-ResistantFrontiers in microbiology · 2021Article
- Epidemiology and control measures of an OXA-48-producing Enterobacteriaceae hospital outbreak.Infection prevention in practice · 2020Article
- Epidemiology of β-Lactamase-Producing Pathogens.Clinical microbiology reviews · 2020Review
- A hybrid simulation model approach to examine bacterial genome sequencing during a hospital outbreak.BMC infectious diseases · 2020Article
- Proof-of-concept trial of the combination of lactitol withGut pathogens · 2020Article
- The Global Ascendency of OXA-48-Type Carbapenemases.Clinical microbiology reviews · 2019Review
- Emergence of Klebsiella pneumoniae Harboring theAntimicrobial agents and chemotherapy · 2018Article
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9 authors.
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Abstract
The main objective of our study was to describe the epidemiological and microbiological features of an oligoclonal hospital-wide outbreak caused by OXA-48-producing Enterobacteriaceae (OXA-48-PE). OXA-48 is a carbapenemase belonging to Ambler class D beta-lactamases, identified frequently in the Mediterranean and Southern European countries, and associated with several Enterobacteriaceae species. An outbreak of OXA-48-PE with a complex epidemic pattern was detected in January 2011. Initial control measures included contact precautions and the reinforcement of infection control practices, but despite all efforts made, the epidemiological situation hardly changed and new measures were implemented during 2013. An observational retrospective study was performed to describe the main features of the outbreak and to analyse the cumulative incidence (CI) trends. Eight hundred and 16 patients colonised or infected by OXA-48-PE were identified during the 2-year period (January 2013-December 2014), female 46%, mean age (s.d.), 71.6 (15.2). The samples isolated in the incident cases were rectal swabs (80%), urine samples (10.7%), blood samples (2.8%) and other clinical samples (6.6%). The most frequent OXA-48-PE was Klebsiella pneumoniae. Eleven different clones were identified, but K. pneumoniae sequence types 11 and 405 were predominant: ST11 (64.2%) and ST405 (29.3%). OXA-48-PE CI trend suffered a statistically significant change in August 2013, which continued the following months. Though we could not eradicate the outbreak, we observed a statistically significant drop in CI after an intervention for OXA-48-PE control, based on patient cohort, active surveillance, electronic alerts and reinforcement of infection control measures in a tertiary hospital.
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