Evidence map›Paper›PMID 29458383›Full record

ArticleEnvironmental health : a global access science source2018

Cumulative exposure to environmental pollutants during early pregnancy and reduced fetal growth: the Project Viva cohort.

Lisa B Rokoff, Sheryl L Rifas-Shiman, Brent A Coull, Andres Cardenas, Antonia M Calafat, Xiaoyun Ye, Alexandros Gryparis, Joel Schwartz, Sharon K Sagiv, Diane R Gold and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Environmental health : a global access science source, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 4 pooled it
3.0field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 4 syntheses or guidelines pooled it, 41 citations in OpenAlex.

  1. Pooled it
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  12. As andEnvironmental science and pollution research international · 2022
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  18. Per- and Polyfluoroalkyl Substances Differentially Inhibit Placental Trophoblast Migration and Invasion In Vitro.Toxicological sciences : an official journal of the Society of Toxicology · 2020
    Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 7 institutions in 2 countries.

Lisa B RokoffDivision of Chronic Disease Research Across the Lifecourse, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, 401 Park Drive, Suite 401, Boston, MA, 02215, USA. lrokoff@mail.harvard.edu.
Sheryl L Rifas-ShimanDivision of Chronic Disease Research Across the Lifecourse, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, 401 Park Drive, Suite 401, Boston, MA, 02215, USA.
Brent A CoullDepartment of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Andres CardenasDivision of Chronic Disease Research Across the Lifecourse, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, 401 Park Drive, Suite 401, Boston, MA, 02215, USA.
Antonia M CalafatDivision of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Xiaoyun YeDivision of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Alexandros GryparisDepartment of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School, Athens, Greece.
Joel SchwartzDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Sharon K SagivCenter for Environmental Research and Children's Health, University of California, Berkeley, CA, USA.
Diane R GoldDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Emily OkenDivision of Chronic Disease Research Across the Lifecourse, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, 401 Park Drive, Suite 401, Boston, MA, 02215, USA.
Abby F FleischPediatric Endocrinology and Diabetes, Maine Medical Center, Portland, ME, USA.
Harvard University · USHarvard Pilgrim Health Care · USBerkeley Public Health Division · USCenters for Disease Control and Prevention · USMaine Medical Center · USNational and Kapodistrian University of Athens · GRNational Center for Environmental Health · US

Funding

Prenatal environmental determinants of health in young adulthood: a lifecourse approachR01HD034568 · NICHD · HARVARD PILGRIM HEALTH CARE, INC. · PI Marie-France Hivert, Emily Oken · 1998 to 2026
$20.6M
Common and distinct early environmental influences on cardiometabolic and respiratory health: Mechanisms and methodsUG3OD023286 · OD · HARVARD PILGRIM HEALTH CARE, INC. · PI KLEINMAN, KENNETH P., OKEN, EMILY · 2016 to 2017
$4.1M
Prenatal exposure to polyfluoroalkyl chemicals (PFCs)and child growth and developmentR01ES021447 · NIEHS · UNIVERSITY OF CALIFORNIA BERKELEY · PI SAGIV, SHARON K. · 2012 to 2016
$2.8M
Patient-oriented Research in Maternal Perinatal Overnutrition and Child AdiposityK24HD069408 · NICHD · HARVARD PILGRIM HEALTH CARE, INC. · PI OKEN, EMILY · 2011 to 2015
$844k
Air Pollution Exposure during Pregnancy, Maternal Glycemia, and OffspringGrowthK23ES024803 · NIEHS · MAINEHEALTH · PI FLEISCH, ABBY · 2015 to 2019
$835k
Eunice Kennedy Shriver National Institute of Child Health and Human Development K24HD069408Eunice Kennedy Shriver National Institute of Child Health and Human Development R01HD034568NICHD NIH HHS K24 HD069408NICHD NIH HHS R01 HD034568NIEHS NIH HHS K23 ES024803NIEHS NIH HHS K23ES024803NIEHS NIH HHS R01 ES021447NIEHS NIH HHS R01ES021447NIH HHS UG3 OD023286NIH HHS UG3OD023286U.S. Environmental Protection Agency RD-834798
6 · The paper itself

Abstract

backgroundReduced fetal growth is associated with perinatal and later morbidity. Prenatal exposure to environmental pollutants is linked to reduced fetal growth at birth, but the impact of concomitant exposure to multiple pollutants is unclear. The purpose of this study was to examine interactions between early pregnancy exposure to cigarette smoke, traffic pollution, and select perfluoroalkyl substances (PFASs) on birth weight-for-gestational age (BW/GA).

methodsAmong 1597 Project Viva mother-infant pairs, we assessed maternal cigarette smoking by questionnaire, traffic pollution at residential address by black carbon land use regression model, and plasma concentration of select PFASs in early pregnancy. We calculated sex-specific BW/GA z-scores, an index of fetal growth, from national reference data. We fit covariate-adjusted multi-pollutant linear regression models and examined interactions between exposures, using a likelihood-ratio test to identify a best-fit model.

resultsTwo hundred six (13%) mothers smoked during pregnancy. Mean [standard deviation (SD)] for black carbon was 0.8 (0.3) μg/m

conclusionsConcurrent prenatal exposures to maternal smoking, black carbon, and PFOS are additively associated with lower fetal growth, whereas PFNA may attenuate associations of smoking and black carbon with lower fetal growth. It is important to examine interactions between multiple exposures in relation to health outcomes, as effects may not always be additive and may shed light on biological pathways.

Indexed as

AdultAlkanesulfonic AcidsEnvironmental PollutantsFemaleFetal DevelopmentFluorocarbonsHumansMassachusettsMaternal ExposurePregnancyProspective StudiesSootTobacco Smoke PollutionTraffic-Related PollutionAlkanesulfonic AcidsEnvironmental PollutantsFluorocarbonshexadecafluoro-nonanoic acidperfluorooctane sulfonic acidSootTobacco Smoke PollutionAir pollutionBirth weightEpidemiologyPerfluoroalkyl substancesPregnancySmoking

Identifiers

PMID29458383
PMCPMC5819079
OpenAlexW2795853234

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.