Observational studyRespiratory research2018
Relationship of CT-quantified emphysema, small airways disease and bronchial wall dimensions with physiological, inflammatory and infective measures in COPD.
Observational study in Respiratory research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 36 citations in OpenAlex.
- Airway Response to Dual Bronchodilation and Its Association with Inflammatory Markers in Treatment-Naïve Chronic Obstructive Pulmonary Disease: A Quantitative Computed Tomography Study.Life (Basel, Switzerland) · 2026Article
- Article
- Impact of emphysema on biomarkers in hospitalized COPD patients with community-acquired pneumonia: a retrospective study.BMC pulmonary medicine · 2026Article
- Cardiopulmonary Exercise Testing and Quantitative Chest CT in COPD: The Stronger Association of Emphysema Over Airway Thickness with Functional Impairment.International journal of chronic obstructive pulmonary disease · 2026Article
- Analysis of perioperative risk factors and development of predictive models for complications following CT guided microwave ablation of pulmonary nodules.Scientific reports · 2025Article
- The utility of quantitative computed tomography in cohort studies of chronic obstructive pulmonary disease: a narrative review.Journal of thoracic disease · 2023Review
- Computer-assisted evaluation of small airway disease in CT scans of Iran-Iraq war victims of chemical warfare by a locally developed software: comparison between different quantitative methods.BMC medical imaging · 2023Article
- Clinical Implications of Low Absolute Blood Eosinophil Count in the SPIROMICS COPD Cohort.Chest · 2023Article
- Analysis of Airway Thickening and Serum Cytokines in COPD Patients with Frequent Exacerbations: A Heart of the Matter.International journal of chronic obstructive pulmonary disease · 2023Article
- Early Diagnosis of High-Risk Chronic Obstructive Pulmonary Disease Based on Quantitative High-Resolution Computed Tomography Measurements.International journal of chronic obstructive pulmonary disease · 2023Article
- Prediction of exercise-induced desaturation in COPD patients without resting hypoxemia: a retrospective study.BMC pulmonary medicine · 2022Article
- Emphysema Progression at CT by Deep Learning Predicts Functional Impairment and Mortality: Results from the COPDGene Study.Radiology · 2022Observational
- Bullous Parametric Response Map for Functional Localization of COPD.Journal of digital imaging · 2022Article
- The CT pulmonary vascular parameters and disease severity in COPD patients on acute exacerbation: a correlation analysis.BMC pulmonary medicine · 2021Article
- Imbalance Between Injury and Defense in the COPD Emphysematous Phenotype.Frontiers in medicine · 2021Review
- Extracellular Vesicles as Mediators of Cellular Cross Talk in the Lung Microenvironment.Frontiers in medicine · 2020Review
- Role of medical and molecular imaging in COPD.Clinical and translational medicine · 2019Review
- Assessing pulmonary hypertension in COPD. Is there a role for computed tomography?International journal of chronic obstructive pulmonary disease · 2019Review
- Inflammation and endothelial activation in early adulthood are associated with future emphysema: the CARDIA Lung Study.The European respiratory journal · 2019Article
- Impact of radiologically stratified exacerbations: insights into pneumonia aetiology in COPD.Respiratory research · 2018Observational
Corrections and comments
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Authors and funding
15 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCOPD is a complex, heterogeneous disease characterised by progressive development of airflow limitation. Spirometry provides little information about key aspects of pathology and is poorly related to clinical outcome, so other tools are required to investigate the disease. We sought to explore the relationships between quantitative CT analysis with functional, inflammatory and infective assessments of disease to identify the utility of imaging to stratify disease to better predict outcomes and disease response.
methodsPatients from the AERIS study with moderate-very severe COPD underwent HRCT, with image analysis determining the quantity of emphysema (%LAA
results122 subjects were included in this analysis. Emphysema and small airways disease had independent associations with airflow obstruction (β = - 0.34, p < 0.001 and β = - 0.56, p < 0.001). %LAA
conclusionsThis study provides further validation for the use of quantitative CT measures of emphysema and small airways disease in COPD as they showed strong associations with pulmonary physiology and functional status. In contrast to this quantitative CT measures showed few convincing associations with biological measures of disease, suggesting it is not an effective tool at measuring disease activity.
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