ReviewNeuroImage2019
MRI techniques to measure arterial and venous cerebral blood volume.
Review in NeuroImage, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
58 citing papers in PubMed, 115 citations in OpenAlex.
- A Generalized Approach to Solving Deep Learning-Based Quantitative Susceptibility Mapping and Quantitative Blood Oxygen Level Dependent Magnitude (QSM + qBOLD or QQ) for Oxygen Extraction Fraction (OEF) Mapping Across Diverse Acquisition Schemes.Magnetic resonance in medicine · 2026Article
- Advances in hypoxia-modulated blood oxygen level-dependent MRI: a narrative review of physiological principles and applications for glioblastoma imaging.Magma (New York, N.Y.) · 2026Review
- Distinguishing Muscle Oxygen Saturation from Tissue Oxygen Saturation: Accuracy, Limitations, and Practical Utility in Muscle Oximetry.Sports medicine - open · 2026Article
- Exploring the Role of Vascular Factors and Tissue Properties in Pulsatile Brain Deformation.NMR in biomedicine · 2026Article
- TMagnetic resonance in medicine · 2026Article
- Rapid whole-brain venous cerebral blood volume mapping using velocity-selective venous-spin-labeling with 3D GRASE.NeuroImage · 2025Article
- A Lumped Parameter Modelling Study of Leukoaraiosis Suggests Its Vascular Pathophysiology May Be Similar to Normal-Pressure Hydrocephalus.Brain sciences · 2025Article
- A Lumped Parameter Modelling Study of Idiopathic Intracranial Hypertension Suggests the CSF Formation Rate Varies with the Capillary Transmural Pressure.Brain sciences · 2025Article
- Reduced removal of waste products from energy metabolism takes center stage in human brain aging.Scientific reports · 2025Article
- Brain Ischemia in Alzheimer's Disease May Partly Counteract the Disruption of the Blood-Brain Barrier.Brain sciences · 2025Article
- Relationship Between Signals from Cerebral near Infrared Spectroscopy Sensor Technology and Objectively Measured Cerebral Blood Volume: A Systematic Scoping Review.Sensors (Basel, Switzerland) · 2025Article
- Abnormal arteriolar blood volume measured by 3D inflow-based vascular-space-occupancy (iVASO) MRI and resting-state BOLD fluctuations at 7 T in individuals with recent-onset schizophrenia.Psychoradiology · 2025Article
- Review
- A Lumped Parameter Model Suggests That Infusion Studies Overestimate the Cerebrospinal Fluid Outflow Resistance in Normal Pressure Hydrocephalus.Brain sciences · 2024Article
- A lumped parameter modelling study of cerebral autoregulation in normal pressure hydrocephalus suggests the brain chooses to be ischemic.Scientific reports · 2024Article
- The Networking Brain: How Extracellular Matrix, Cellular Networks, and Vasculature Shape the In Vivo Mechanical Properties of the Brain.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Review
- On the optimization of 3D inflow-based vascular-space-occupancy (iVASO) MRI for the quantification of arterial cerebral blood volume (CBVa).Magnetic resonance in medicine · 2024Article
- The Development of Non-Invasive Optical Brain Pulse Monitoring: A Review.Medical devices (Auckland, N.Z.) · 2024Review
- Validation of the Openwater wearable optical system: cerebral hemodynamic monitoring during a breath-hold maneuver.Neurophotonics · 2024Article
- Cerebral oxygen metabolism from MRI susceptibility.NeuroImage · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 7 institutions in 3 countries.
Funding
Abstract
The measurement of cerebral blood volume (CBV) has been the topic of numerous neuroimaging studies. To date, however, most in vivo imaging approaches can only measure CBV summed over all types of blood vessels, including arterial, capillary and venous vessels in the microvasculature (i.e. total CBV or CBVtot). As different types of blood vessels have intrinsically different anatomy, function and physiology, the ability to quantify CBV in different segments of the microvascular tree may furnish information that is not obtainable from CBVtot, and may provide a more sensitive and specific measure for the underlying physiology. This review attempts to summarize major efforts in the development of MRI techniques to measure arterial (CBVa) and venous CBV (CBVv) separately. Advantages and disadvantages of each type of method are discussed. Applications of some of the methods in the investigation of flow-volume coupling in healthy brains, and in the detection of pathophysiological abnormalities in brain diseases such as arterial steno-occlusive disease, brain tumors, schizophrenia, Huntington's disease, Alzheimer's disease, and hypertension are demonstrated. We believe that the continual development of MRI approaches for the measurement of compartment-specific CBV will likely provide essential imaging tools for the advancement and refinement of our knowledge on the exquisite details of the microvasculature in healthy and diseased brains.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.