Evidence map›Paper›PMID 29458149›Full record

ArticleFree radical biology & medicine2018

Age-dependent oxidation of extracellular cysteine/cystine redox state (E

Yuxuan Zheng, Jeffrey D Ritzenthaler, Tom J Burke, Javier Otero, Jesse Roman, Walter H Watson

Abstract read
In one paragraph

Article in Free radical biology & medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.6field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 26 citations in OpenAlex.

  1. Review
  2. Article
  3. Aging and lung diseases: Unraveling mechanisms and therapeutic targets.Chinese medical journal pulmonary and critical care medicine · 2025
    Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
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  10. Review
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  12. Article
  13. Autoinhibition by Iodide Ion in the Methionine-Iodine Reaction.The journal of physical chemistry. A · 2020
    Article
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Yuxuan ZhengDepartment of Pharmacology and Toxicology, University of Louisville School of Medicine, 505 South Hancock Street, Louisville, KY 40202, United States. Electronic address: y0zhen14@exchange.louisville.edu.
Jeffrey D RitzenthalerDepartment of Medicine, Divisions of Gastroenterology, Hepatology and Nutrition, and Pulmonary, Critical Care, & Sleep Medicine, University of Louisville School of Medicine, 550 South Jackson Street, Louisville, KY 40202, United States. Electronic address: j0ritz01@exchange.louisville.edu.
Tom J BurkeDepartment of Medicine, Divisions of Gastroenterology, Hepatology and Nutrition, and Pulmonary, Critical Care, & Sleep Medicine, University of Louisville School of Medicine, 550 South Jackson Street, Louisville, KY 40202, United States. Electronic address: tjburk01@exchange.louisville.edu.
Javier OteroDepartment of Medicine, Divisions of Gastroenterology, Hepatology and Nutrition, and Pulmonary, Critical Care, & Sleep Medicine, University of Louisville School of Medicine, 550 South Jackson Street, Louisville, KY 40202, United States. Electronic address: javier.otero1@upr.edu.
Jesse RomanDepartment of Pharmacology and Toxicology, University of Louisville School of Medicine, 505 South Hancock Street, Louisville, KY 40202, United States; Department of Medicine, Divisions of Gastroenterology, Hepatology and Nutrition, and Pulmonary, Critical Care, & Sleep Medicine, University of Louisville School of Medicine, 550 South Jackson Street, Louisville, KY 40202, United States; Robley Rex Veterans Affairs Medical Center, 800 Zorn Avenue, Louisville, KY 40206, United States. Electronic address: j0roma02@exchange.louisville.edu.
Walter H WatsonDepartment of Pharmacology and Toxicology, University of Louisville School of Medicine, 505 South Hancock Street, Louisville, KY 40202, United States; Department of Medicine, Divisions of Gastroenterology, Hepatology and Nutrition, and Pulmonary, Critical Care, & Sleep Medicine, University of Louisville School of Medicine, 550 South Jackson Street, Louisville, KY 40202, United States. Electronic address: whwats01@exchange.louisville.edu.
University of Louisville · US

Funding

Role of oxidized linoleic acid metabolites in the pathogenesis of alcoholic liver diseaseP20GM113226 · NIGMS · UNIVERSITY OF LOUISVILLE · PI ZHANG, XIANG · 2016 to 2025
$24.1M
The Role of Nutrition in the Development/Progression of Alcohol-Induced Organ InjuryP50AA024337 · NIAAA · UNIVERSITY OF LOUISVILLE · PI SHIRISH S BARVE · 2016 to 2026
$17.9M
The Impact of Oxidative Stress on HIV-induced Lung DiseaseU01HL121807 · NHLBI · UNIVERSITY OF LOUISVILLE · PI RAMIREZ, JULIO ALBERTO, ROMAN, JESSE · 2013 to 2017
$2.7M
Receptor-mediated effects of ethanol in lung tissue injury and repairR01AA019953 · NIAAA · UNIVERSITY OF LOUISVILLE · PI ROMAN, JESSE · 2012 to 2016
$1.6M
Nicotine-induced fibronectin expression in lung injury and repairI01BX000216 · VA · VETERANS HEALTH ADMINISTRATION · PI ROMAN, JESSE · 2009 to 2018
–
BLRD VA I01 BX000216NHLBI NIH HHS U01 HL121807NIAAA NIH HHS P50 AA024337NIAAA NIH HHS R01 AA019953NIGMS NIH HHS P20 GM113226
6 · The paper itself

Abstract

Aging is associated with progressive oxidation of the extracellular environment. The redox state of human plasma, defined by the concentrations of cysteine (Cys) and cystine (CySS), becomes more oxidized as we age. Recently, we showed that fibroblasts isolated from the lungs of young and old mice retain this differential phenotype; old cells produce and maintain a more oxidizing extracellular redox potential (E

Indexed as

AgingAmino Acid Transport System y+AnimalsCysteineCystineFemaleFibroblastsLungMiceMice, Inbred C57BLOxidation-ReductionAmino Acid Transport System y+CysteineCystineSlc7a11 protein, mouseAgingCys/CySSFibroblastsRedox stateSlc7a11

Identifiers

PMID29458149
PMCPMC5884717
OpenAlexW2790107617

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.