Evidence map›Paper›PMID 29458140›Full record

ReviewMatrix biology : journal of the International Society for Matrix Biology2019

Hyaluronan in adipogenesis, adipose tissue physiology and systemic metabolism.

Yi Zhu, Ilja L Kruglikov, Yucel Akgul, Philipp E Scherer

Open access · hybridAbstract readReview
In one paragraph

Review in Matrix biology : journal of the International Society for Matrix Biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 73 citations in OpenAlex.

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  12. Long term observation ofRegenerative therapy · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Yi ZhuTouchstone Diabetes Center, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Ilja L KruglikovWellcomet GmbH, Karlsruhe, Germany.
Yucel AkgulDepartment of Plastic Surgery, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Philipp E SchererTouchstone Diabetes Center, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address: Philipp.Scherer@UTSouthwestern.edu.
The University of Texas Southwestern Medical Center · US

Funding

The role of AgRP/Auga-ALK pathway in FGF21's brain action on agingP01AG051459 · NIA · YALE UNIVERSITY · PI VISHWA DEEP DIXIT · 2016 to 2026
$25.7M
Novel Mechanisms Regulating the Adipocyte-Brain-Hepatocyte AxisP01DK088761 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI SCHERER, PHILIPP E · 2010 to 2019
$17.4M
Adiponectin, A Protein Secreted From Adipose TissueR01DK055758 · NIDDK · YESHIVA UNIVERSITY · PI SCHERER, PHILIPP E · 2000 to 2024
$10.9M
White Adipose Tissue Physiology, Mitochondrial Function and AdiponectinR01DK099110 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI PHILIPP E SCHERER · 2013 to 2026
$6.7M
Gap Junction Dependent and Independent Roles of Connexin43 in Metabolic TissuesR00DK114498 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI ZHU, YI · 2020 to 2022
$733k
Gap Junction Dependent and Independent Roles of Connexin43 in Metabolic TissuesK99DK114498 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI ZHU, YI · 2017 to 2018
$182k
NIA NIH HHS P01 AG051459NIDDK NIH HHS K99 DK114498NIDDK NIH HHS P01 DK088761NIDDK NIH HHS R00 DK114498NIDDK NIH HHS R01 DK055758NIDDK NIH HHS R01 DK099110Wellcome Trust
6 · The paper itself

Abstract

Hyaluronic acid (HA, also known as hyaluronan), is a non-sulfated linear glycosaminoglycan polymer consisting of repeating disaccharide units of d-glucuronic acid and N-acetyl-d-glucosamine abundantly present in the extracellular matrix. The sizes of hyaluronic acid polymers range from 5000 to 20,000,000 Da in vivo, and the functions of HA are largely dictated by its size. Due to its high biocompatibility, HA has been commonly used as soft tissue filler as well as a major component of biomaterial scaffolds in tissue engineering. Several studies have implicated that HA may promote differentiation of adipose tissue derived stem cells in vitro or in vivo when used as a supporting scaffold. However, whether HA actually promotes adipogenesis in vivo and the subsequent metabolic effects of this process are unclear. This review summarizes some recent publications in the field and discusses the possible directions and approaches for future studies, focusing on the role of HA in the adipose tissue.

Indexed as

AdipogenesisAdipose TissueAnimalsCell DifferentiationCell ProliferationExtracellular MatrixHumansHyaluronic AcidMolecular WeightStem CellsTissue EngineeringTissue ScaffoldsHyaluronic AcidAdipogenesisAdipose tissueDermal fillerExtracellular matrixHyaluronanHyaluronic acid

Identifiers

PMID29458140
PMCPMC6534160
OpenAlexW2793924314

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.