ArticleExperimental neurology2018
Modest enhancement of sensory axon regeneration in the sciatic nerve with conditional co-deletion of PTEN and SOCS3 in the dorsal root ganglia of adult mice.
Article in Experimental neurology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed, 37 citations in OpenAlex.
- AAV Vector-Mediated Modulation of Signaling Pathways in Neurological Disorders: Insights From Cellular, Animal, and Human Studies.Cell biochemistry and function · 2026Review
- Chitosan/PLGA-based tissue engineered nerve grafts with SKP-SC-EVs enhance sciatic nerve regeneration in dogs through miR-30b-5p-mediated regulation of axon growth.Bioactive materials · 2024Article
- Heat shock factor 1 promotes neurite outgrowth and suppresses inflammation in the severed spinal cord of geckos.Neural regeneration research · 2023Article
- The RSK2-RPS6 axis promotes axonal regeneration in the peripheral and central nervous systems.PLoS biology · 2023Article
- Muscle-derived stem cell exosomes with overexpressed miR-214 promote the regeneration and repair of rat sciatic nerve after crush injury to activate the JAK2/STAT3 pathway by targeting PTEN.Frontiers in molecular neuroscience · 2023Article
- Mapping and targeted viral activation of pancreatic nerves in mice reveal their roles in the regulation of glucose metabolism.Nature biomedical engineering · 2022Article
- Age‑related differences for expression of the nerve‑specific proteins after peripheral nerve injury.Experimental and therapeutic medicine · 2022Article
- Review
- Harnessing rAAV-retro for gene manipulations in multiple pathways that are interrupted after spinal cord injury.Experimental neurology · 2022Article
- Motoneuron-Specific PTEN Deletion in Mice Induces Neuronal Hypertrophy and Also Regeneration after Facial Nerve Injury.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- MicroRNA-29a-3p Regulates SH-SY5Y Cell Proliferation and Neurite Growth through Interaction with PTEN-PI3K/AKT/mTOR Signaling Pathway.Disease markers · 2022Article
- Article
- Co-targeting B-RAF and PTEN Enables Sensory Axons to Regenerate Across and Beyond the Spinal Cord Injury.Frontiers in molecular neuroscience · 2022Article
- Photobiomodulation promotes neural regeneration when compared to simvastatin treatment in a sciatic nerve crush model.Lasers in medical science · 2021Article
- Transcriptomic sex differences in sensory neuronal populations of mice.Scientific reports · 2020Article
- Temporal changes in the spinal cord transcriptome after peripheral nerve injury.Neural regeneration research · 2020Article
- Neuroregeneration and plasticity: a review of the physiological mechanisms for achieving functional recovery postinjury.Military Medical Research · 2020Review
- [Research progress on intrinsic signaling pathways in axon regeneration].Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2020Review
- An update on PTEN modulators - a patent review.Expert opinion on therapeutic patents · 2019Review
- [Changes in expression of microRNA-221 and phosphatase and tension protein homologue in nerve stump after peripheral nerve injury].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2019Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Axons within the peripheral nervous system are capable of regeneration, but full functional recovery is rare. Recent work has shown that conditional deletion of two key signaling inhibitors of the PI3K and Jak/Stat pathways-phosphatase and tensin homolog (PTEN) and suppressor of cytokine signaling-3 (SOCS3), respectively-promotes regeneration of normally non-regenerative central nervous system axons. Moreover, in studies of optic nerve regeneration, co-deletion of both PTEN and SOCS3 has an even greater effect. Here, we test the hypotheses (1) that PTEN deletion enhances axon regeneration following sciatic nerve crush and (2) that PTEN/SOCS3 co-deletion further promotes regeneration. PTEN
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.