Evidence map›Paper›PMID 29457976›Full record

ArticleJournal of medicinal chemistry2018

Radiosynthesis and in Vivo Evaluation of [

J S Dileep Kumar, Kiran Kumar Solingapuram Sai, Jaya Prabhakaran, Hakeem R Oufkir, Gayathri Ramanathan, Christopher T Whitlow, Hima Dileep, Akiva Mintz, J John Mann

Abstract read
In one paragraph

Article in Journal of medicinal chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
1.6field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 36 citations in OpenAlex.

  1. Article
  2. Imaging Microtubule Dynamics In Vivo in Human Brain: Optimal Quantification Based on a Test-Retest Study.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2026
    Article
  3. Amyloid Beta Oligomers as Early Triggers of Neuronal Cytoskeleton Dysfunction in Alzheimer's Disease.Pathophysiology : the official journal of the International Society for Pathophysiology · 2026
    Review
  4. Imaging microtubule dynamics: A new frontier in biomarker development for neurodegenerative diseases.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Review
  5. Article
  6. Article
  7. Exploring microtubule dynamics in Alzheimer's disease: Longitudinal assessment using [Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024
    Article
  8. Development and Optimization ofACS pharmacology & translational science · 2023
    Review
  9. Article
  10. Article
  11. Binding Parameters of [Pharmaceuticals (Basel, Switzerland) · 2023
    Article
  12. [Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2022
    Article
  13. Article
  14. Review
  15. In vivo evaluation of a microtubule PET ligand, [Pharmacological reports : PR · 2022
    Article
  16. Article
  17. Review
  18. Effect of ethanol and cocaine on [Molecular biology reports · 2021
    Article
  19. Preliminary Evaluations of [Frontiers in neuroscience · 2021
    Article
  20. PET Imaging of [Molecules (Basel, Switzerland) · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

J S Dileep KumarMolecular Imaging and Neuropathology Division , New York State Psychiatric Institute , 1051 Riverside Drive , New York , New York 10032 , United States.ORCID 0000-0001-6688-3991
Kiran Kumar Solingapuram SaiDepartment of Radiology , Wake Forest Medical Center , Winston Salem , North Carolina 27157 , United States.
Jaya PrabhakaranMolecular Imaging and Neuropathology Division , New York State Psychiatric Institute , 1051 Riverside Drive , New York , New York 10032 , United States.
Hakeem R OufkirDepartment of Radiology , Wake Forest Medical Center , Winston Salem , North Carolina 27157 , United States.
Gayathri RamanathanDepartment of Radiology , Wake Forest Medical Center , Winston Salem , North Carolina 27157 , United States.
Christopher T WhitlowDepartment of Radiology , Wake Forest Medical Center , Winston Salem , North Carolina 27157 , United States.
Hima DileepMolecular Imaging and Neuropathology Division , New York State Psychiatric Institute , 1051 Riverside Drive , New York , New York 10032 , United States.
Akiva MintzDepartment of Radiology , Wake Forest Medical Center , Winston Salem , North Carolina 27157 , United States.
J John MannMolecular Imaging and Neuropathology Division , New York State Psychiatric Institute , 1051 Riverside Drive , New York , New York 10032 , United States.
Wake Forest University · USColumbia University Irving Medical Center · USNew York Psychoanalytic Society and Institute · US

Funding

Wake Forest Clinical and Translational Science AwardUL1TR001420 · NCATS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ARD, JAMY D, FOLEY, KRISTIE L · 2015 to 2023
$32.3M
Wake Forest Alzheimer's Disease Core CenterP30AG049638 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI RAPP, STEPHEN R · 2016 to 2020
$12.2M
IMAGING T CELLS BY POSITRON EMISSION TOMOGRAPHYR01CA163587 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI NAJJAR, AMER M · 2012 to 2016
$2.9M
Development of GSK-3beta PET radioligands for in vivo imaging in brainR21MH112037 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI PRABHAKARAN, JAYA · 2016 to 2017
$452k
NCATS NIH HHS UL1 TR001420NCI NIH HHS R01 CA163587NIA NIH HHS P30 AG049638NIMH NIH HHS R21 MH112037
6 · The paper itself

Abstract

Abnormalities of microtubules (MTs) are implicated in the pathogenesis of many CNS diseases. Despite the potential of an MT imaging agents, no PET ligand is currently available for in vivo imaging of MTs in the brain. We radiolabeled [

Indexed as

AnimalsBrainCarbon RadioisotopesLigandsMiceMicrotubulesPositron-Emission TomographyQuinazolinesRatsCarbon RadioisotopesLigandsQuinazolinesverubulin

Identifiers

PMID29457976
PMCPMC6637745
OpenAlexW2788727669

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.