ArticleEnvironmental microbiology2018
A network of regulators promotes dehydration tolerance in Escherichia coli.
Article in Environmental microbiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 19 citations in OpenAlex.
- DksA-Dependent Stringent Stress Response Drives Virulence and Gastrointestinal Persistence ofbioRxiv : the preprint server for biology · 2026Article
- RpoS and the bacterial general stress response.Microbiology and molecular biology reviews : MMBR · 2024Review
- New layers of regulation of the general stress response sigma factor RpoS.Frontiers in microbiology · 2024Review
- Effect of Lyoprotective Agents on the Preservation of Survival of aMicroorganisms · 2023Article
- DNA-Binding Protein Dps ProtectsBiology · 2023Article
- Enhancing cell resistance for production of mixed microbiological reference materials with Salmonella and coliforms by freeze-drying.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2022Article
- The ArcAB Two-Component System: Function in Metabolism, Redox Control, and Infection.Microbiology and molecular biology reviews : MMBR · 2022Review
- Osmotic stress induces long-term biofilm survival in Liberibacter crescens.BMC microbiology · 2022Article
- A Broad Continuum of E. coli Traits in Nature Associated with the Trade-off Between Self-preservation and Nutritional Competence.Microbial ecology · 2022Article
- Two-component system ArcBA modulates cell motility and biofilm formation inFrontiers in plant science · 2022Article
- Universal functions of the σ finger in alternative σ factors during transcription initiation by bacterial RNA polymerase.RNA biology · 2021Article
- Sterilization efficiency of pathogen-contaminated cottons in a laundry machine.Journal of microbiology (Seoul, Korea) · 2020Article
- Article
- TheViruses · 2018Article
- Desiccation tolerance in Acinetobacter baumannii is mediated by the two-component response regulator BfmR.PloS one · 2018Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The ability to survive conditions of low water activity is critical for the survival of many bacteria in the environment and facilitates disease transmission through food and contaminated surfaces. However, the molecular mechanisms that enable bacteria to withstand this condition remain poorly understood. Here we describe a network of regulators in Escherichia coli that are important for this bacterium to survive dehydration. We found that the transcriptional regulator DksA and the general stress response regulator RpoS play a critical role. From a plasmid genomic library screen, we identified two additional regulators, Crl and ArcZ, that promote dehydration tolerance through modulation of RpoS. We also found that LexA, RecA and ArcA contribute to survival. Our results identify key regulators that enable E. coli to tolerate dehydration and suggest a hierarchical network is involved in protection against cellular damage associated with this stress.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.