ArticleArthritis & rheumatology (Hoboken, N.J.)2018
A Multicenter Study of the Validity and Reliability of Responses to Hand Cold Challenge as Measured by Laser Speckle Contrast Imaging and Thermography: Outcome Measures for Systemic Sclerosis-Related Raynaud's Phenomenon.
Article in Arthritis & rheumatology (Hoboken, N.J.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
41 citing papers in PubMed, 2 syntheses or guidelines pooled it, 84 citations in OpenAlex.
- Vasodilators for primary Raynaud's phenomenon.The Cochrane database of systematic reviews · 2021Pooled it
- Behaviour change interventions for the management of Raynaud's phenomenon: a systematic literature review.BMJ open · 2018Pooled it
- An exploratory trial of a single dose of CAM2043 (treprostinil subcutaneous depot) in SSc-related RP.Rheumatology (Oxford, England) · 2025Trial
- Impact of acute caffeine intake on local tolerance to cold before and after total sleep deprivation.Experimental physiology · 2025Trial
- A phase 2 trial investigating the efficacy and safety of the mPGES-1 inhibitor vipoglanstat in systemic sclerosis-related Raynaud's.Rheumatology (Oxford, England) · 2025Trial
- A phase 2 trial investigating the effects of the angiotensin II type 2 receptor agonist C21 in systemic sclerosis-related Raynaud's.Rheumatology (Oxford, England) · 2023Trial
- Reliability and Reproducibility of Laser Speckle Contrast Imaging for Assessment of Superficial Perfusion in Patients with High-Risk Feet: A Feasibility Study.Nursing reports (Pavia, Italy) · 2026Article
- Assessing post-cold challenge recovery of thermography as a potential outcome measure in trials of SSc-related Raynaud's phenomenon.Scientific reports · 2026Article
- Lips in health and in systemic sclerosis: relevant physiology, pathogenesis, existing therapeutic approaches and unmet needs.Journal of scleroderma and related disorders · 2026Article
- Assessing the Health and Functionality of the Microcirculation Using Thermal Imaging.Journal of biophotonics · 2026Review
- Microvascular ultrasonography for quantitative evaluation of nailfold vasculature in systemic sclerosis.BMC medical imaging · 2026Observational
- Skin transient receptor potential channels expression and microvascular reactivity to cooling in primary and secondary Raynaud's phenomenon.Physiological reports · 2025Article
- Using a smartphone app to monitor Raynaud's attacks and quantify skin colour changes-towards objective outcome measures for Raynaud's.Rheumatology (Oxford, England) · 2025Article
- Artificial intelligence-based Raynaud's quantification index (ARTIX): an objective mobile-based tool for patient-centered assessment of Raynaud's phenomenon.Arthritis research & therapy · 2025Article
- Clinical Application of Infrared Thermography in Rheumatic Diseases: A Systematic Review.Mediterranean journal of rheumatology · 2025Article
- Infrared thermography for the diagnosis and monitoring of Raynaud's phenomenon: current evidence and future directions.Reumatologia · 2025Review
- Thermography Sensor to Assess Motor and Sensitive Neuromuscular Sequels of Brain Damage.Sensors (Basel, Switzerland) · 2024Observational
- Mobile phone thermography of the toes in patients with systemic sclerosis-a pilot study.Rheumatology advances in practice · 2024Article
- Mobile phone thermal imaging as an ambulatory assessment tool in Raynaud's phenomenon.Rheumatology (Oxford, England) · 2023Article
- Multiexposure laser speckle contrast analysis system calibration limited by perfusion-dependent scattering on the skin.Journal of biomedical optics · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
22 authors at 9 institutions in 1 country.
Funding
Abstract
objectiveReliable and objective outcome measures to facilitate clinical trials of novel treatments for systemic sclerosis (SSc)-related Raynaud's phenomenon (RP) are badly needed. Laser speckle contrast imaging (LSCI) and thermography are noninvasive measures of perfusion that have shown excellent potential. This multicenter study was undertaken to determine the reliability and validity of a hand cold challenge protocol using LSCI, standard thermography, and low-cost cell phone/mobile phone thermography (henceforth referred to as mobile thermography) in patients with SSc-related RP.
methodsPatients with RP secondary to SSc were recruited from 6 UK tertiary care centers. The patients underwent cold challenge on 2 consecutive days. Changes in cutaneous blood flow/skin temperature at each visit were imaged simultaneously using LSCI, standard thermography, and mobile thermography. Measurements included area under the curve (AUC) for reperfusion/rewarming and maximum blood flow rate/skin temperature after rewarming (MAX). Test-retest reliability was assessed using intraclass correlation coefficients (ICCs). Estimated latent correlations (estimated from multilevel models, taking values between -1 and 1; denoted as rho values) were used to assess the convergent validity of LSCI and thermography.
resultsIn total, 159 patients (77% with limited cutaneous SSc) were recruited (84% female, median age 63.3 years). LSCI and standard thermography both had substantial reliability, with ICCs for the reperfusion/rewarming AUC of 0.67 (95% confidence interval [95% CI] 0.54, 0.76) and 0.68 (95% CI 0.58, 0.80), respectively, and ICCs for the MAX of 0.64 (95% CI 0.52, 0.75) and 0.72 (95% CI 0.64, 0.81), respectively. Very high latent correlations were present for the AUCs of LSCI and thermography (ρ = 0.94; 95% CI 0.87, 1.00) and for the AUCs of standard and mobile thermography (ρ = 0.98; 95% CI 0.94, 1.00).
conclusionThis is the first multicenter study to examine the reliability and validity of cold challenge using LSCI and thermography in patients with SSc-related RP. LSCI and thermography both demonstrated good potential as outcome measures. LSCI, standard thermography, and mobile thermography had very high convergent validity.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.