ArticleStem cells translational medicine2018
Delivery of Allogeneic Adipose Stem Cells in Polyethylene Glycol-Fibrin Hydrogels as an Adjunct to Meshed Autografts After Sharp Debridement of Deep Partial Thickness Burns.
Article in Stem cells translational medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 2 syntheses or guidelines pooled it, 52 citations in OpenAlex.
- Effectiveness of the adipose stem cells in burn wound healing: literature review.Cell and tissue banking · 2022Pooled it
- Stem Cell-Based Tissue Engineering for the Treatment of Burn Wounds: A Systematic Review of Preclinical Studies.Stem cell reviews and reports · 2022Pooled it
- Fibrin scaffolds for angiogenesis in soft tissue models: a systematic review.Bioactive materials · 2026Review
- Blood Plasma, Fibrinogen or Fibrin Biomaterial for the Manufacturing of Skin Tissue-Engineered Products and Other Dermatological Treatments: A Systematic Review.Journal of functional biomaterials · 2025Review
- Plasma-rich fibrin gel and adipose-derived allogeneic mesenchymal stem cells: innovation in the treatment of second-degree deep burn wound; characterization and in-vivo study.Cell and tissue banking · 2025Article
- A Comprehensive Review: Advances in Mesenchymal Stem Cell Applications for Burn Wound Repair.Stem cells international · 2025Review
- [Cell therapy and wound repair].Zhonghua shao shang yu chuang mian xiu fu za zhi · 2024Review
- Tailoring the secretome composition of mesenchymal stem cells to augment specific functions of epidermal regeneration: anFrontiers in medical technology · 2023Article
- Spongy-like hydrogels prevascularization with the adipose tissue vascular fraction delays cutaneous wound healing by sustaining inflammatory cell influx.Materials today. Bio · 2022Article
- Administration Methods of Mesenchymal Stem Cells in the Treatment of Burn Wounds.European burn journal · 2022Review
- Article
- Review
- Adipose stem cells-released extracellular vesicles as a next-generation cargo delivery vehicles: a survey of minimal information implementation, mass production and functional modification.Stem cell research & therapy · 2022Article
- Polymeric Hydrogel Scaffolds: Skin Tissue Engineering and Regeneration.Advanced pharmaceutical bulletin · 2022Review
- Preparation and Characterization of Polysaccharide-Based Hydrogels for Cutaneous Wound Healing.Polymers · 2022Article
- Sources, Characteristics, and Therapeutic Applications of Mesenchymal Cells in Tissue Engineering.Tissue engineering and regenerative medicine · 2022Review
- The effectiveness of skin allografts in survival rate of patients with major burns.International journal of burns and trauma · 2022Article
- Advances of hydrogel combined with stem cells in promoting chronic wound healing.Frontiers in chemistry · 2022Review
- Age-related alteration in characteristics, function, and transcription features of ADSCs.Stem cell research & therapy · 2021Article
- ASCs derived from burn patients are more prone to increased oxidative metabolism and reactive oxygen species upon passaging.Stem cell research & therapy · 2021Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Harvesting of autografts results in donor site morbidities and is limited in scenarios such as large total body surface area burns. In these instances, coverage is increased by meshing grafts at the expense of delayed biologic closure. Moreover, graft meshing increases the likelihood of contraction and hypertrophic scarring, limits range of motion, and worsens cosmesis. Many tissue engineering technologies have touted the promise of adipose-derived stem cells (ASCs) for burn wounds. The primary objective of the current study was to determine feasibility and efficacy of in situ ASC delivery via PEGylated fibrin (FPEG) hydrogels as adjuncts to meshed split thickness skin grafts in a porcine model. Deep partial thickness burns were created on the dorsum of anesthetized Yorkshire pigs, and subsequently debrided on post-burn day 4. After debridement, wounds were treated with: split thickness skin grafts (STSG); meshed STSG (mSTSG); and mSTSG + FPEG with increasing doses of ASCs. We show that FPEG hydrogels can be delivered in situ to prevent the contraction seen after meshing of STSG. Moreover, ASCs delivered in FPEG dose-dependently increase blood vessel size which significantly correlates with CD31 protein levels. The current study reports a dual-action adjunct therapy to autografting administered in situ, wherein FPEG acts as both scaffolding to prevent contraction, and as a delivery vehicle for ASCs to accelerate angiogenesis. This strategy may be used to incorporate other biologics for generating tissue engineered products aimed at improving wound healing and minimizing donor sites or scarring. Stem Cells Translational Medicine 2018;7:360-372.
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