Evidence map›Paper›PMID 29457274›Full record

ArticleClinical transplantation2018

Impact of the kidney allocation system on young pediatric recipients.

William Fiske Parker, Lainie Friedman Ross, J Richard Thistlethwaite, Amy E Gallo

Abstract read
In one paragraph

Article in Clinical transplantation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Deceased Donor Kidney Allocation Changes and Pediatric Recipients: Are We Making the Best Match?American journal of kidney diseases : the official journal of the National Kidney Foundation · 2026
    Article
  2. Article
  3. Delayed graft function and long-term outcomes after deceased donor kidney transplantation: insights from mate-kidney analysis.Transplant international : official journal of the European Society for Organ Transplantation · 2026
    Article
  4. Article
  5. Scoring donor lungs for graft failure risk: The Lung Donor Risk Index (LDRI).American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2024
    Article
  6. Article
  7. Article
  8. Transplant access for children: there is more to be done.Pediatric nephrology (Berlin, Germany) · 2023
    Article
  9. Article
  10. Article
  11. Organ allocation in pediatric abdominal transplant.Seminars in pediatric surgery · 2022
    Article
  12. Donor considerations in pediatric kidney transplantation.Pediatric nephrology (Berlin, Germany) · 2021
    Review
  13. Changes in offer and acceptance patterns for pediatric kidney transplant candidates under the new Kidney Allocation System.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2020
    Article
  14. Pediatric deceased donor kidney transplant outcomes under the Kidney Allocation System.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2019
    Article
  15. Article
  16. It is time to revise the kidney allocation system to restore the pediatric advantage.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

William Fiske ParkerDepartment of Medicine, University of Chicago, Chicago, IL, USA.ORCID 0000-0002-6000-3153
Lainie Friedman RossDepartment of Medicine, University of Chicago, Chicago, IL, USA.
J Richard ThistlethwaiteMacLean Center for Clinical Medical Ethics, University of Chicago, Chicago, IL, USA.
Amy E GalloDepartment of Surgery, Stanford University, Palo Alto, CA, USA.

Funding

TRANSLATIONAL RESEARCH UNIVERSITY OF CHICAGO: CLINICAL TRIALSUL1RR024999 · NCRR · UNIVERSITY OF CHICAGO · PI SOLWAY, JULIAN · 2007 to 2011
$25.3M
RESEARCH TRAINING IN RESPIRATORY BIOLOGYT32HL007605 · NHLBI · UNIVERSITY OF CHICAGO · PI Yun Fang, Gokhan M. Mutlu · 1985 to 2026
$18.1M
NCRR NIH HHS UL1 RR024999NHLBI NIH HHS T32 HL007605
6 · The paper itself

Abstract

The kidney allocation system (KAS) altered pediatric candidate prioritization. We determined KAS's impact on pediatric kidney recipients by examining delayed graft function (DGF) rates from 2010 to 2016. A propensity score-matched pediatric recipients pre- and post-KAS. A semiparametric decomposition analysis estimated the contributions of KAS-related changes in donor characteristics and dialysis time on DGF rate. The unadjusted odds of DGF were 69% higher post-KAS for young (<10 years at listing) recipients (N = 1153, P = .02) but were not significantly increased for older pediatric (10-17 years at listing) recipients (N = 2624, P = .48). Post-KAS, young recipients received significantly fewer pediatric (<18 years) donor kidneys (21% vs 32%, P < .01) and had longer median pretransplant dialysis time (603 vs 435 days, P < .01). After propensity score matching, post-KAS status increased the odds of DGF in young recipients 71% (OR 1.71, 95% CI 1.01-2.46). In decomposition analysis, 24% of the higher DGF rate post-KAS was attributable to donor characteristics and 19% to increased recipient dialysis time. In a confirmatory survival analysis, DGF was associated with a 2.2 times higher risk of graft failure (aHR2.28, 95% CI 1.46-3.54). In conclusion, KAS may lead to worse graft survival outcomes in children. Allocation changes should be considered.

Indexed as

ChildChild, PreschoolDelayed Graft FunctionFemaleFollow-Up StudiesGlomerular Filtration RateGraft RejectionGraft SurvivalHumansKidney Failure, ChronicKidney Function TestsKidney TransplantationMalePostoperative ComplicationsPrognosisResource Allocationclassification systemsdelayed graft functionkidney (allograft) function/dysfunctionpediatric transplantationwaitlist management

Identifiers

PMID29457274
PMCPMC6029615

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.