Evidence map›Paper›PMID 29457146›Full record

ArticleCell, stem cells and regenerative medicine2017

Periodontal Biology: Stem Cells, Bmp2 Gene, Transcriptional Enhancers, and Use of Sclerostin Antibody and Pth for Treatment of Periodontal Disease and Bone Loss.

Stephen E Harris, Michael Rediske, Rebecca Neitzke, Audrey Rakian

Open access · diamondAbstract read
In one paragraph

Article in Cell, stem cells and regenerative medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Stephen E HarrisDepartment of Periodontics, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA.
Michael RediskeDepartment of Periodontics, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA.
Rebecca NeitzkeDepartment of Periodontics, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA.
Audrey RakianDepartment of Periodontics, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA.
The University of Texas Health Science Center at San Antonio · US

Funding

Bmp2 and Sost Genes and Their Interactions in Stem Cells of the PeriodontiumR01DE024797 · NIDCR · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI HARRIS, STEPHEN EUBANK · 2015 to 2019
$1.9M
NIDCR NIH HHS R01 DE024797
6 · The paper itself

Abstract

The periodontium is a complex tissue with epithelial components and a complex set of mesodermal derived alveolar bone, cellular and a cellular cementum, and tendon like ligaments (PDL). The current evidence demonstrates that the major pool of periodontal stem cells is derived from a population of micro vascular associated aSMA-positive stem/progenitor (PSC) cells that by lineage tracing form all three major mesodermal derived components of the periodontium. With

Indexed as

Bmp2EpigenomicsPeriodontiumPthSclerostinStem Cells

Identifiers

PMID29457146
PMCPMC5813290
OpenAlexW2801157327

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.