Evidence map›Paper›PMID 29457144›Full record

ArticleCurrent opinion in biomedical engineering2017

Functional Near Infrared Spectroscopy: Enabling Routine Functional Brain Imaging.

Meryem A Yücel, Juliette J Selb, Theodore J Huppert, Maria Angela Franceschini, David A Boas

Registry-linked trialOpen access · greenAbstract read
In one paragraph

Article in Current opinion in biomedical engineering, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06897670 (Identifying Cerebral Hemodynamic Patterns in Mood Disorders and Mild Cognitive Impairment), which is not on this map. Cited by 121 papers.

0numbers the graph read from it
0cells of the map it votes in
121citing papers in PubMed
14.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06897670 recruitingnot on this mapstarted 2025, after this paper: background citation

Identifying Cerebral Hemodynamic Patterns in Mood Disorders and Mild Cognitive Impairment: A Functional Near-Infrared Spectroscopy (fNIRS) Study

TypeobservationalSponsorMayo ClinicRan2025 to 2028Enrolled200ConditionsMajor Depressive Disorder, Bipolar Disorder, Mild Cognitive ImpairmentArmsObservational assessment using functional near-infrared spectroscopy (fNIRS), a noninvasive, portable brain imaging tool that measures changes in brain blood flow and oxygen levels.
3 · Its place in the literature

Who cites it

121 citing papers in PubMed, 211 citations in OpenAlex.

  1. Trial
  2. Article
  3. Listening to a Consonant Chord Progression during Live Face-to-Face Gaze Enhances Neural Activity in Social Systems.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
  4. Article
  5. Hand movements prediction via fNIRS and AI algorithms.BMC medical informatics and decision making · 2026
    Article
  6. Review
  7. Article
  8. Article
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  11. Review
  12. Review
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61 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Meryem A YücelAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.
Juliette J SelbAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.
Theodore J HuppertDepartment of Radiology and Bioengineering, University of Pittsburg, Pittsburg, PA, USA.
Maria Angela FranceschiniAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.
David A BoasAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.
Harvard University · USAthinoula A. Martinos Center for Biomedical Imaging · USBoston University · USPittsburg State University · US

Funding

VARIABILITY, STABILITY & SMOOTHNESS OF WALKINGP30AG024827 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Caterina Rosano · 2004 to 2026
$28.6M
Project 4P41EB015896 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI ROSEN, BRUCE R · 2012 to 2018
$9.8M
Objective Pain Measures in Awake Sedated, Anesthetized Individuals with NIRSR01GM104986 · NIGMS · MASSACHUSETTS GENERAL HOSPITAL · PI BOAS, DAVID A, BORSOOK, DAVID · 2013 to 2016
$2.1M
Perioperative Measures of Nociception using NIRSR01GM122405 · NIGMS · BOSTON CHILDREN'S HOSPITAL · PI KUSSMAN, BARRY DAVID · 2017 to 2020
$1.6M
Establishing an fNIRS Ecosystem for Open Software-Hardware DisseminationR24NS104096 · NINDS · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI BOAS, DAVID A · 2018 to 2021
$1.1M
NIA NIH HHS P30 AG024827NIBIB NIH HHS P41 EB015896NIGMS NIH HHS R01 GM104986NIGMS NIH HHS R01 GM122405NINDS NIH HHS R24 NS104096
6 · The paper itself

Abstract

Functional Near-Infrared Spectroscopy (fNIRS) maps human brain function by measuring and imaging local changes in hemoglobin concentrations in the brain that arise from the modulation of cerebral blood flow and oxygen metabolism by neural activity. Since its advent over 20 years ago, researchers have exploited and continuously advanced the ability of near infrared light to penetrate through the scalp and skull in order to non-invasively monitor changes in cerebral hemoglobin concentrations that reflect brain activity. We review recent advances in signal processing and hardware that significantly improve the capabilities of fNIRS by reducing the impact of confounding signals to improve statistical robustness of the brain signals and by enhancing the density, spatial coverage, and wearability of measuring devices respectively. We then summarize the application areas that are experiencing rapid growth as fNIRS begins to enable routine functional brain imaging.

Identifiers

PMID29457144
PMCPMC5810962
OpenAlexW2761310417

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.