Evidence map›Paper›PMID 29457008›Full record

ReviewSkin appendage disorders2018

A Review of Platelet-Rich Plasma: History, Biology, Mechanism of Action, and Classification.

Rubina Alves, Ramon Grimalt

8 registry-linked trialsAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Skin appendage disorders, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 8 registered trials, which are not on this map. Cited by 275 papers, 21 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
275citing papers in PubMed, 21 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03890172 unknown statusnot on this mapstarted 2019, after this paper: background citation

Efficacy of Platelets Rich Plasma as a Therapeutic Tool in Chronic Non Healing Diabetic Foot Ulcers

TypeobservationalSponsorAssiut UniversityRan2019 to 2021Enrolled60ConditionsDiabetic Foot UlcerArms20-100 ml venous blood will be drawn the from patient into sterilized centrifuge tube ,following centrifuge to separate PRP and at the bed side and tricked onto the ulcer twice weekly, standard treatment
NCT04797377 nacompletednot on this mapstarted 2021, after this paper: background citation

Effects of Autologous Intraovarian Platelet Rich Plasma in Women With Poor Ovarian Response

TypeinterventionalSponsorNadezhda Women's Health HospitalRan2021 to 2021Enrolled66ConditionsPoor Ovarian ReserveArmsAutologous ovarian PRP injection
NCT05112718 phase2 / phase3unknown statusnot on this mapstarted 2021, after this paper: background citation

The Use of Platelet Rich Plasma (PRP) as a Treatment of the Female Stress Urinary Incontinence

TypeinterventionalSponsorNational and Kapodistrian University of AthensRan2021 to 2022Enrolled50ConditionsUrinary Incontinence, Stress Urinary IncontinenceArmsPlatelet Rich Plasma Injections, Normal Saline Injections
NCT05251831 early_phase1completednot on this mapstarted 2020, after this paper: background citation

Evaluation of Activated Platelet Rich Plasma Versus Non-Activated Platelet Rich Plasma in Alopecia Areata

TypeinterventionalSponsorAl-Azhar UniversityRan2020 to 2021Enrolled40ConditionsAlopecia AreataArmsIntradermal injection
NCT05711355 nacompletednot on this mapstarted 2022, after this paper: background citation

A Randomized Trial of the Effects of Platelet-Rich Plasma on Postoperative Complications After Meningomyelocele Sac Repair

TypeinterventionalSponsorYuzuncu Yil UniversityRan2022 to 2022Enrolled40ConditionsMeningomyelocele/Spina BifidaArmsUse of Platelet-Rich Plasma after meningomyelocele sac repair, meningomyelocele sac repair
NCT05769283 nacompletednot on this mapstarted 2023, after this paper: background citation

Vaginal Injection of Platelet Rich Plasma for Improvement of Sexual Function: A Randomized Control Trial

TypeinterventionalSponsorMedstar Health Research InstituteRan2023 to 2025Enrolled52ConditionsSexual Behavior, Sexual ActivityArmsPlatelet Rich Plasma, Saline
NCT07306611 phase1 / phase2completednot on this mapstarted 2024, after this paper: background citation

Regenerative Treatment of Female Genital Atrophy

TypeinterventionalSponsorAndreiaAntunesRan2024 to 2025Enrolled30ConditionsVulvo Vaginal AtrophyArmsMesotherapy with Autologous Platelet-Rich Plasma (PRP) to vulvovaginal area, Mesotherapy with saline solution, Platelet-Poor Plasma Gel
NCT07504575 recruitingnot on this mapstarted 2026, after this paper: background citation

Effect of Platelet-rich Plasma (PRP) on the Quality of Donor Semen During Cryopreservation

TypeobservationalSponsorInstituto Valenciano de Infertilidad, IVI AlicanteRan2026 to 2028Enrolled20ConditionsSperm Cryodamage
3 · Its place in the literature

Who cites it

275 citing papers in PubMed, 21 syntheses or guidelines pooled it.

  1. Role of autologous platelet-rich plasma for recurrent or refractory macular hole in the era of various flap techniques: a meta-analysis.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026
    Pooled it
  2. [Adjunctive agents for nerve blocks/local injections in the treatment of zoster-associated pain: A systematic review based on levels of evidence].Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2026
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  4. Regenerative Approaches in Vulvar Lichen Sclerosus: A Systematic Review.International journal of molecular sciences · 2025
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  11. Autologous platelet-rich plasma for assisted reproduction.The Cochrane database of systematic reviews · 2024
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  13. Platelet-rich plasma in chronic Achilles tendinopathy.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2023
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215 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Rubina AlvesDepartment of Dermatology, Universitat International Catalunya, Barcelona, Spain.
Ramon GrimaltDepartment of Dermatology, Universitat International Catalunya, Barcelona, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Platelet-rich plasma (PRP) is currently used in different medical fields. The interest in the application of PRP in dermatology has recently increased. It is being used in several different applications as in tissue regeneration, wound healing, scar revision, skin rejuvenating effects, and alopecia. PRP is a biological product defined as a portion of the plasma fraction of autologous blood with a platelet concentration above the baseline. It is obtained from the blood of patients collected before centrifugation. The knowledge of the biology, mechanism of action, and classification of the PRP should help clinicians better understand this new therapy and to easily sort and interpret the data available in the literature regarding PRP. In this review, we try to provide useful information for a better understanding of what should and should not be treated with PRP.

Indexed as

Autologous therapyBiologyMechanism of actionPlasmaPlatelet-rich plasma

Identifiers

PMID29457008
PMCPMC5806188

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

and 2 more above

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.