Evidence map›Paper›PMID 29456968›Full record

ArticleFrontiers in cellular and infection microbiology2018

Alternative Splicing of Differentiated Myeloid Cell Transcripts after Infection by

J Stephen Dumler, Sara H Sinclair, Amol C Shetty

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Frontiers in microbiology · 2024
    Article
  3. Article
  4. Innate immunity in rickettsial infections.Frontiers in cellular and infection microbiology · 2023
    Review
  5. Frontiers in cellular and infection microbiology · 2022
    Article
  6. Frontiers in public health · 2020
    Article
  7. Article
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

J Stephen DumlerDepartment of Pathology, F. Edward Hébert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, United States.
Sara H SinclairIndependent Researcher, Tsaile, AZ, United States.
Amol C ShettyInstitute for Genome Sciences, University of Maryland, Baltimore, Baltimore, MD, United States.
Uniformed Services University of the Health Sciences · USUniversity of Maryland, Baltimore · US

Funding

EHRLICHIA-GRANULOCYTE INTERACTIONS AND INFECTIONR01AI044102 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI DUMLER, JOHN STEPHEN · 2000 to 2019
$5.3M
NIAID NIH HHS R01 AI044102
6 · The paper itself

Abstract

Eukaryotic proteome diversity exceeds that encoded within individual genes, and results in part from alternative splicing events of pre-messenger RNA. The diversity of these splicing events can shape the outcome in development and differentiation of normal tissues, and is important in pathogenic circumstances such as cancer and some heritable conditions. A role for alternative splicing of eukaryotic genes in response to viral and intracellular bacterial infections has only recently been recognized, and plays an important role in providing fitness for microbial survival, while potentially enhancing pathogenicity.

Indexed as

Alternative SplicingTranscriptomeAnaplasma phagocytophilumCell DifferentiationComputational BiologyEhrlichiosisGene Expression ProfilingGene OntologyHL-60 CellsHumansMyeloid CellsSpliceosomesTranscriptional ActivationAnaplasma phagocytophilumgene ontologyintracellular infectionRNA isoformsRNAseqspliceosome

Identifiers

PMID29456968
PMCPMC5801399
OpenAlexW2790402709

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.