Evidence map›Paper›PMID 29456793›Full record

ArticleACS medicinal chemistry letters2018

Synthesis of Novel Tetrahydroisoquinoline CXCR4 Antagonists with Rigidified Side-Chains.

Edgars Jecs, Eric J Miller, Robert J Wilson, Huy H Nguyen, Yesim A Tahirovic, Brook M Katzman, Valarie M Truax, Michelle B Kim, Katie M Kuo, Tao Wang and 5 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS medicinal chemistry letters, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Discovery ofACS medicinal chemistry letters · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 1 country.

Edgars JecsDepartment of Chemistry, Emory University, 1515 Dickey Drive NE, Atlanta, Georgia 30322, United States.
Eric J MillerDepartment of Chemistry, Emory University, 1515 Dickey Drive NE, Atlanta, Georgia 30322, United States.
Robert J WilsonDepartment of Chemistry, Emory University, 1515 Dickey Drive NE, Atlanta, Georgia 30322, United States.
Huy H NguyenDepartment of Chemistry, Emory University, 1515 Dickey Drive NE, Atlanta, Georgia 30322, United States.
Yesim A TahirovicDepartment of Chemistry, Emory University, 1515 Dickey Drive NE, Atlanta, Georgia 30322, United States.
Brook M KatzmanDepartment of Chemistry, Emory University, 1515 Dickey Drive NE, Atlanta, Georgia 30322, United States.
Valarie M TruaxDepartment of Chemistry, Emory University, 1515 Dickey Drive NE, Atlanta, Georgia 30322, United States.
Michelle B KimDepartment of Chemistry, Emory University, 1515 Dickey Drive NE, Atlanta, Georgia 30322, United States.
Katie M KuoDepartment of Chemistry, Emory University, 1515 Dickey Drive NE, Atlanta, Georgia 30322, United States.
Tao WangBristol-Myers Squibb Research & Development, Princeton, New Jersey 08543, United States.
Chi S SumBristol-Myers Squibb Research & Development, Princeton, New Jersey 08543, United States.
Mary E CvijicBristol-Myers Squibb Research & Development, Princeton, New Jersey 08543, United States.
Gretchen M SchroederBristol-Myers Squibb Research & Development, Princeton, New Jersey 08543, United States.
Lawrence J WilsonDepartment of Chemistry, Emory University, 1515 Dickey Drive NE, Atlanta, Georgia 30322, United States.
Dennis C LiottaDepartment of Chemistry, Emory University, 1515 Dickey Drive NE, Atlanta, Georgia 30322, United States.
Emory University · USBristol-Myers Squibb (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A structure-activity relationship study of potent TIQ15-derived CXCR4 antagonists is reported. In this investigation, the TIQ15 side-chain was constrained to improve its drug properties. The cyclohexylamino congener

Identifiers

PMID29456793
PMCPMC5807867
OpenAlexW2779870812

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.