ArticleJournal of children's orthopaedics2018
Management of osteonecrosis of the femoral head in children with sickle cell disease: results of conservative and operative treatments at skeletal maturity.
Article in Journal of children's orthopaedics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.
- Bone Infarcts and Tumorigenesis-Is There a Connection? A Mini-Mapping Review.International journal of environmental research and public health · 2022Pooled it
- A Stage-Based, Multidisciplinary Approach to Therapy-Associated Osteonecrosis in Pediatric Oncology Patients.Journal of the Pediatric Orthopaedic Society of North America · 2026Review
- Retrospective cohort study assessing radiological outcomes and risk factors for progression of femoral head osteonecrosis in children with sickle cell disease, following bisphosphonate therapy, CD-BMAC and proximal femoral reorientation osteotomy.Journal of children's orthopaedics · 2026Article
- Osteonecrosis in sickle cell disease: Contemporary orthopaedic practice and outcomes across African healthcare settings.SICOT-J · 2026Article
- Shelf acetabuloplasty in children diagnosed with osteonecrosis of the femoral head secondary to acute lymphoblastic leukaemia.BMC musculoskeletal disorders · 2025Article
- [Femoral head necrosis after femoral neck fracture-A lifelong burden].Unfallchirurgie (Heidelberg, Germany) · 2025Article
- Review
- Article
- Operative Management of Avascular Necrosis of the Femoral Head in Skeletally Immature Patients: A Systematic Review.Life (Basel, Switzerland) · 2022Review
- Application of protective weight-bearing in osteonecrosis of the femoral head: A systematic review and meta-analysis of randomized controlled trials and observational studies.Frontiers in surgery · 2022Review
- Avascular necrosis after femoral neck fracture in children and adolescents: poor prognosis and risk factors.International orthopaedics · 2021Article
- Chronic organ injuries in children with sickle cell disease.Haematologica · 2021Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeSickle cell disease (SCD) is the most common cause of femoral head osteonecrosis (ONFH) during childhood with an overall prevalence of 10%. In children, spontaneous revascularization can occur, as in Legg-Calve-Perthes disease. Consequently, the aim of treatment is to restore proper hip containment to prevent joint arthritis. This is the first study reporting long-term results at skeletal maturity of non-operative and surgical treatments for ONFH in SCD children.
methodsAll children with ONFH due to SCD were retrospectively reviewed. At initial evaluation, extension of osteonecrosis was radiographically defined using Catterall, lateral pillar Herring and Ficat classifications. Subluxation of the femoral head with Reimers migration index > 30% required surgical treatment including femoral varus osteotomy and/or pelvic osteotomies. Conservative treatment including non-weight bearing and physiotherapy was performed in the remaining cases. Outcomes were assessed at skeletal maturity using the Harris Hip Score (HHS) and the Stulberg classification. Total hip arthroplasty and Stulberg 5 were defined as failures.
resultsA total of 25 hips in 17 patients were included (mean follow-up 7.5 years SD 3.4). Mean age at diagnosis was 11.4 years SD 2.9. In all, 15 hips (60%) were classified Catterall 3 and 4 and Herring B and C. A total of 13 patients (52%) underwent surgical treatment. At skeletal maturity, mean HHS was good (81 SD 17), 12 hips (48%) were classified Stulberg 1 and 2, seven hips (28%) were classified Stulberg 3 and 4.
conclusionBoth treatments led to good functional results with 75% of congruent hips at skeletal maturity. LEVEL OF EVIDENCE: IV.
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