ArticleExperimental and therapeutic medicine2018
Correlation of vitamin D receptor with bronchial asthma in children.
Article in Experimental and therapeutic medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The serum level of vitamin D and prevalence of vitamin D deficiency among children with asthma in Asia and Africa: a systematic review and meta-analysis.Archives of public health = Archives belges de sante publique · 2024Pooled it
- Genetic Diversity in Bronchial Asthma Susceptibility: Exploring the Role of Vitamin D Receptor Gene Polymorphisms in Varied Geographic Contexts.International journal of molecular sciences · 2024Article
- Association of polymorphisms of vitamin D gene in children with asthma and allergic rhinitis - Hospital based study.Heliyon · 2024Article
- Vitamin D receptor and vitamin D binding protein gene polymorphisms in patients with asthma: a pilot study.BMC pulmonary medicine · 2023Article
- Meta-Analysis of Vitamin D Receptor Gene Polymorphisms in Childhood Asthma.Frontiers in pediatrics · 2022Article
- Vitamin D receptor gene polymorphisms in atopy.Immunity, inflammation and disease · 2021Review
- Association of vitamin D receptor gene polymorphisms in North Indian children with asthma: a case-control study.International journal of molecular epidemiology and genetics · 2021Article
- Association of vitamin D gene polymorphisms in children with asthma - A systematic review.Heliyon · 2020Review
- Association of vitamin D genetic pathway with asthma susceptibility in the Kurdish population.Journal of clinical laboratory analysis · 2020Article
- Genetic Variants Associated with Bronchial Asthma Specific to the Population of the Russian Federation.Acta naturaeArticle
- Analysis of changes in the expression levels of peripheral blood immunoregulatory T Lymphocytes in children with bronchial asthma accompanied by recurrent infection.Pakistan journal of medical sciencesArticle
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Authors and funding
3 authors.
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No grant is acknowledged in the PubMed record.
Abstract
This study was designed to investigate the correlation of vitamin D receptor (VDR) gene polymorphism with bronchial asthma in children. Seventy patients admitted to Daqing Longnan Hospital and diagnosed as bronchial asthma for the first time from April 2015 to May 2017 were selected as observation group. Patients received routine treatment and intervention. Seventy healthy subjects admitted to hospital during the same period were enrolled as the control group. Vitamin D gene polymorphism was detected by polymerase chain reaction-restriction fragment length polymorphism assay; the levels of total serum immunoglobulin E (IgE) in the two groups were determined by electrochemiluminescence immunoassay; lung function levels in patients were measured using PowerCube (Germany) pulmonary function instrument before and after treatment, and the relationship between VDR gene polymorphism and lung function in children with bronchial asthma was analyzed. The difference in comparison of base frequency of rs1544410 locus of VDR gene had no statistical significance between the two groups (P>0.05). The locus CC frequency of rs7975232 of VDR gene in observation group was lower in the observation group than that in the control group (P<0.05); the locus AC and AA frequencies of rs7975232 of VDR gene were higher in the observation group than those in the control group (P<0.05). The level of vitamin D was lower in the observation group than that in the control group (P<0.05); the level of total serum IgE was higher in the observation group than that in the control group (P<0.05). The forced expiratory volume in 1 sec (FEV1), peak expiratory flow (PEF) and the ratio of FEV1 to forced vital capacity (FVC) in children with bronchial asthma in the observation group were higher after treatment than those before treatment (P<0.05). The correlation research displayed that VDR gene polymorphism was negatively correlated with lung function levels in children with bronchial asthma (P<0.05). The results showed that children with bronchial asthma are often accompanied by different degrees of changes in VDR gene polymorphism, which is negatively correlated with the severity of asthma, so vitamin D should be strengthened to ameliorate the prognosis of children.
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