ArticleExperimental and therapeutic medicine2018
Full-thickness conjunctival flap covering surgery combined with amniotic membrane transplantation for severe fungal keratitis.
Article in Experimental and therapeutic medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.
- Management of corneal perforations in dry eye disease: Preferred practice pattern guidelines.Indian journal of ophthalmology · 2023Guideline
- Modified tectonic corneoscleral graft technique for treating devastating corneoscleral infections.BMC ophthalmology · 2024Article
- Real-life experience on the effectiveness of conjunctival flap and amniotic membrane graft in the treatment of refractory fungal corneal ulcer.Japanese journal of ophthalmology · 2024Observational
- Coniochaeta mutabilis keratitis with an unusual mode of transmission treated with penetrating keratoplasty and systemic antifungals.American journal of ophthalmology case reports · 2023Article
- Management of Filamentous Fungal Keratitis: A Pragmatic Approach.Journal of fungi (Basel, Switzerland) · 2022Review
- Update on the management of fungal keratitis.International ophthalmology · 2021Review
- Adjunctive Green Thermal Laser Photocoagulation for Treatment of Resistant Infectious Keratitis.Clinical ophthalmology (Auckland, N.Z.) · 2021Article
- Corneal transplantation and eye banking practices during COVID-19-related lockdown period in India from a network of tertiary eye care centers.Indian journal of ophthalmology · 2020Article
- Conjunctival flap surgery in the management of ocular surface disease (Review).Experimental and therapeutic medicine · 2020Review
- Use of autologous fascia lata graft to repair a complex corneal ulcer in a mare.Irish veterinary journal · 2020Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fungal keratitis is a severe and common ocular infectious disease. The present study evaluated the efficiency of full-thickness conjunctival flap covering surgery with amniotic membrane transplantation (FCCS + AMT) as a transitional surgery for severe fungal keratitis. A total of 17 patients with severe fungal keratitis without corneal perforation underwent FCCS + AMT between January 2010 and December 2015. The pathogenic factors, preoperative diagnosis and postoperative prognosis of FCCS + AMT at 3 months were evaluated. Subsequently, 7 patients received sclerokeratoplasty, and the best-corrected visual acuity (BCVA) and recurrence ratio were analyzed at 1 month postoperatively. The primary risk factor was agricultural trauma (7 cases), followed by a non-agricultural object entering the eye (3 cases). Preoperatively, there were 10 cases of fungal keratitis positively identified using confocal microscopy and 9 cases positively identified by corneal scrapings. A total of 3 months following FCCS + AMT, the percentage of cases resulting in preservation of the eyeball was 88.24%, with 15/17 patients demonstrating complete conjunctival re-epithelization and a smooth conjunctival surface without any complications. A total of 2 (11.76%) patients experienced melting of the conjunctival flap and development of endophthalmitis, and subsequently underwent ocular evisceration surgery. A total of 7 patients underwent sclerokeratoplasty and the mean logarithm of the minimum angle of resolution BCVA at 1 month was significantly improved (0.689±0.121; P<0.001) compared with preoperative values (2.459±0.037) and BCVA values following FCCS + AMT (2.529±0.066). No recurrence was observed in any of the cases during the follow-up period. Conclusively, FCCS + AMT may be a preferable treatment for severe fungal keratitis of the entire corneal ulcer without perforation, and may save the eyeball and provide a greater opportunity for corneal transplantation.
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