Evidence map›Paper›PMID 29456665›Full record

ArticleExperimental and therapeutic medicine2018

Involvement of TWEAK and the NF-κB signaling pathway in lupus nephritis.

Fang Sun, Jian Teng, Pengfei Yu, Wenshuang Li, Jing Chang, Honglei Xu

Open access · diamondAbstract read
In one paragraph

Article in Experimental and therapeutic medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 33 citations in OpenAlex.

  1. Article
  2. Systems Pharmacology and Multi-Omics Elucidation ofPharmaceuticals (Basel, Switzerland) · 2025
    Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Mesangial Cells in Lupus Nephritis.Current rheumatology reports · 2022
    Review
  9. Article
  10. Mesangial cell: A hub in lupus nephritis.Frontiers in immunology · 2022
    Review
  11. Article
  12. Article
  13. Toll-Like Receptor as a Potential Biomarker in Renal Diseases.International journal of molecular sciences · 2020
    Review
  14. Article
  15. Article
  16. Review
  17. Review
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Fang SunDepartment of Nephrology, Yantaishan Hospital, Yantai, Shandong 264000, P.R. China.
Jian TengDepartment of Nephrology, Yantaishan Hospital, Yantai, Shandong 264000, P.R. China.
Pengfei YuDepartment of Respiratory Medicine, Yantai Yuhuangding Hospital, Yantai, Shandong 264000, P.R. China.
Wenshuang LiDepartment of Internal Medicine, Laiyang Tuberculosis Prevention Institution, Laiyang, Shandong 265299, P.R. China.
Jing ChangDepartment of Nephrology, Yantaishan Hospital, Yantai, Shandong 264000, P.R. China.
Honglei XuDepartment of Nephrology, Yantaishan Hospital, Yantai, Shandong 264000, P.R. China.
Yantaishan Hospital · CNHeilongjiang Center for Tuberculosis Control and Prevention · CNYuhuangding Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Previous findings have identified that tumor necrosis factor-related weak inducer of apoptosis (TWEAK) is associated with lupus nephritis (LN) activity status; however, the mechanism involved remains unclear. The present study aimed to investigate the roles of TWEAK and the nuclear factor (NF)-κB signaling pathway in LN. TWEAK levels in the blood and urine of patients with LN or non-LN systemic lupus erythematosus were measured by ELISA and compared with those in healthy controls. TWEAK expression and NF-κB transcriptional activity in the kidney were detected by western blotting, and Ki-67 and cluster of differentiation (CD) 68 expression were assessed using immunofluorescence. Additionally, human mesangial cells (HMCs) were cultured

Indexed as

cell proliferationchemotaxishuman glomerular mesangial cellslupus nephritisnuclear factor-κBtumor necrosis factor-related weak inducer of apoptosis

Identifiers

PMID29456665
PMCPMC5795405
OpenAlexW2782467996

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.