ArticleBiotechnology for biofuels2018
Alignment of microbial fitness with engineered product formation: obligatory coupling between acetate production and photoautotrophic growth.
Article in Biotechnology for biofuels, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Synthetic consortia towards photosynthetically derived acetate for heterotrophic production of 1-butanol.Applied microbiology and biotechnology · 2026Article
- Photonic-chemostat engineering for efficient continuous cultivation of cyanobacteria.RSC advances · 2026Article
- Microbial Pathway Thermodynamics: Stoichiometric Models Unveil Anabolic and Catabolic Processes.Life (Basel, Switzerland) · 2024Article
- The adc1 knockout with proC overexpression in Synechocystis sp. PCC 6803 induces a diversion of acetyl-CoA to produce more polyhydroxybutyrate.Biotechnology for biofuels and bioproducts · 2024Article
- Towards evolutionary predictions: Current promises and challenges.Evolutionary applications · 2023Review
- Channeling Anabolic Side Products toward the Production of Nonessential Metabolites: Stable Malate Production inACS synthetic biology · 2021Article
- Combinatorial assembly platform enabling engineering of genetically stable metabolic pathways in cyanobacteria.Nucleic acids research · 2021Article
- Microbial Upgrading of Acetate into Value-Added Products-Examining Microbial Diversity, Bioenergetic Constraints and Metabolic Engineering Approaches.International journal of molecular sciences · 2020Review
- Construction of Fully Segregated Genomic Libraries in Polyploid Organisms Such asACS synthetic biology · 2020Article
- Using osmotic stress to stabilize mannitol production inBiotechnology for biofuels · 2020Article
- A critical comparison of cellular and cell-free bioproduction systems.Current opinion in biotechnology · 2019Review
- Exploiting Day- and Night-Time Metabolism ofACS synthetic biology · 2019Article
- On the use of oxygenic photosynthesis for the sustainable production of commodity chemicals.Physiologia plantarum · 2019Article
- Enhancement of D-mannitol production by fine-tuned expression of mannitol-1-phosphate dehydrogenase in Synechocystis sp. PCC6803.Biotechnology progressArticle
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMicrobial bioengineering has the potential to become a key contributor to the future development of human society by providing sustainable, novel, and cost-effective production pipelines. However, the sustained productivity of genetically engineered strains is often a challenge, as spontaneous non-producing mutants tend to grow faster and take over the population. Novel strategies to prevent this issue of strain instability are urgently needed.
resultsIn this study, we propose a novel strategy applicable to all microbial production systems for which a genome-scale metabolic model is available that aligns the production of native metabolites to the formation of biomass. Based on well-established constraint-based analysis techniques such as OptKnock and FVA, we developed an
conclusionsThis work demonstrates a novel approach to stabilize the production of target compounds in cyanobacteria that culminated in the first report of a photoautotrophic growth-coupled cell factory. The method developed is generic and can easily be extended to any other modeled microbial production system.
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