Evidence map›Paper›PMID 29456556›Full record

ArticleStem cells international2017

Human Umbilical Cord Wharton Jelly-Derived Adult Mesenchymal Stem Cells, in Biohybrid Scaffolds, for Experimental Skin Regeneration.

Pia Montanucci, Camilla di Pasquali, Ivana Ferri, Teresa Pescara, Ilaria Pennoni, Paola Siccu, Angelo Sidoni, Valerio Cervelli, Giuseppe Basta, Riccardo Calafiore

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In one paragraph

Article in Stem cells international, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Biomaterials for extrusion-based bioprinting and biomedical applications.Frontiers in bioengineering and biotechnology · 2024
    Review
  3. Article
  4. Review
  5. Perinatal derivatives: How to best characterize their multimodal functionsFrontiers in bioengineering and biotechnology · 2022
    Review
  6. Review
  7. Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Pia MontanucciDepartment of Medicine, Section of Cardiovascular, Endocrine and Metabolic Clinical Physiology and Laboratory for Endocrine Cell Transplants and Biohybrid Organs, University of Perugia, Piazza Lucio Severi, Perugia, Italy.
Camilla di PasqualiDepartment of Plastic and Reconstructive Surgery, University of Rome "Tor Vergata", Via Montpellier 1, 00133 Rome, Italy.
Ivana FerriDepartment of Experimental Medicine, Section of Pathologic Anatomy and Histology Medical School, University of Perugia, Perugia, Italy.
Teresa PescaraDepartment of Medicine, Section of Cardiovascular, Endocrine and Metabolic Clinical Physiology and Laboratory for Endocrine Cell Transplants and Biohybrid Organs, University of Perugia, Piazza Lucio Severi, Perugia, Italy.ORCID 0000-0002-5247-4959
Ilaria PennoniDepartment of Medicine, Section of Cardiovascular, Endocrine and Metabolic Clinical Physiology and Laboratory for Endocrine Cell Transplants and Biohybrid Organs, University of Perugia, Piazza Lucio Severi, Perugia, Italy.ORCID 0000-0003-2636-4761
Paola SiccuDepartment of Experimental Medicine, Section of Pathologic Anatomy and Histology Medical School, University of Perugia, Perugia, Italy.ORCID 0000-0001-6863-565X
Angelo SidoniDepartment of Experimental Medicine, Section of Pathologic Anatomy and Histology Medical School, University of Perugia, Perugia, Italy.
Valerio CervelliDepartment of Plastic and Reconstructive Surgery, University of Rome "Tor Vergata", Via Montpellier 1, 00133 Rome, Italy.
Giuseppe BastaDepartment of Medicine, Section of Cardiovascular, Endocrine and Metabolic Clinical Physiology and Laboratory for Endocrine Cell Transplants and Biohybrid Organs, University of Perugia, Piazza Lucio Severi, Perugia, Italy.ORCID 0000-0003-1697-8647
Riccardo CalafioreDepartment of Medicine, Section of Cardiovascular, Endocrine and Metabolic Clinical Physiology and Laboratory for Endocrine Cell Transplants and Biohybrid Organs, University of Perugia, Piazza Lucio Severi, Perugia, Italy.ORCID 0000-0002-7560-0081

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The ultimate goal for skin tissue engineering is to regenerate skin lesions to allow the full restoration of morphological and functional properties as what they were before injury. To this end, we have assembled a new prototype of a biomimetic human umbilical cord adult mesenchymal stem cell (hUCMS)/fibrin-based scaffold. We have fully characterized the proposed dermal equivalent (DE) in vitro, to assess morphological, functional, and biological properties of the encased cells. We transplanted DE subcutaneously into immunocompetent rodents, to verify its full biocompatibility. Finally, we studied DE graft effects on full-thickness wounds, in immunocompetent mice to demonstrate its capability to drive the healing process in the absence of significant scarring tissue. The excellent outcome of these in vivo studies fuels hope that this new approach, based on a biohybrid DE, may be applied to the operative treatment of skin lesions (i.e., diabetic foot ulcers and burns) in man.

Identifiers

PMID29456556
PMCPMC5804405

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.