Evidence map›Paper›PMID 29456535›Full record

ArticleFrontiers in immunology2018

Liver X Receptor Agonist Therapy Prevents Diffuse Alveolar Hemorrhage in Murine Lupus by Repolarizing Macrophages.

Shuhong Han, Haoyang Zhuang, Stepan Shumyak, Jingfan Wu, Chao Xie, Hui Li, Li-Jun Yang, Westley H Reeves

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 50 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Roles of macrophages in lupus nephritis.Frontiers in pharmacology · 2024
    Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Shuhong HanDivision of Rheumatology & Clinical Immunology, Department of Medicine, University of Florida, Gainesville, FL, United States.
Haoyang ZhuangDivision of Rheumatology & Clinical Immunology, Department of Medicine, University of Florida, Gainesville, FL, United States.
Stepan ShumyakDivision of Rheumatology & Clinical Immunology, Department of Medicine, University of Florida, Gainesville, FL, United States.
Jingfan WuDivision of Rheumatology & Clinical Immunology, Department of Medicine, University of Florida, Gainesville, FL, United States.
Chao XieDepartment of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL, United States.
Hui LiDepartment of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL, United States.
Li-Jun YangDepartment of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL, United States.
Westley H ReevesDivision of Rheumatology & Clinical Immunology, Department of Medicine, University of Florida, Gainesville, FL, United States.
University of Florida · US

Funding

Using social networks to map and evaluate team science across CTSA hubsUL1TR001427 · NCATS · UNIVERSITY OF FLORIDA · PI MITCHELL, DUANE A. · 2015 to 2024
$37.2M
Pathogenesis on Autoantibodies in Pristane-Induced LupusR01AR044731 · NIAMS · UNIVERSITY OF NORTH CAROLINA CHAPEL HILL · PI REEVES, WESTLEY H · 1997 to 2021
$6.6M
NCATS NIH HHS UL1 TR001427NIAMS NIH HHS R01 AR044731
6 · The paper itself

Abstract

The generation of CD138 CONTROLS: The LXR agonist T0901317 inhibited type I interferon and increased ABCA1 in lupus patients' monocytes and in murine peritoneal macrophages.

Indexed as

AnimalsBenzenesulfonamidesCell PolarityDisease Models, AnimalFluorocarbonsHemorrhageHumansHydrocarbons, FluorinatedHypoxia-Inducible Factor 1, alpha SubunitLiver X ReceptorsLupus Erythematosus, SystemicMacrophages, PeritonealMiceMonocytesSulfonamidesTerpenesBenzenesulfonamidesFluorocarbonsHydrocarbons, FluorinatedHypoxia-Inducible Factor 1, alpha SubunitLiver X ReceptorspristaneSulfonamidesT0901317TerpenesTumor Necrosis Factor-alphadiffuse alveolar hemorrhagehypoxia-inducible factor 1-αinflammationliver X receptorslupusmacrophage polarizationtherapy

Identifiers

PMID29456535
PMCPMC5801423
OpenAlexW2792564419

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.