ArticleJournal of the European Ceramic Society2018
Cobalt-containing bioactive glasses reduce human mesenchymal stem cell chondrogenic differentiation despite HIF-1α stabilisation.
Article in Journal of the European Ceramic Society, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed, 52 citations in OpenAlex.
- SiOAdvanced healthcare materials · 2026Article
- Three-Dimensional Printing and Personalized Bioceramic Scaffolds for Dental and Maxillofacial Applications: A Narrative Review.Dentistry journal · 2026Review
- Comparative mechanical characterisation of 13-93 bioactive glass and hybrid scaffolds for bone regeneration.Scientific reports · 2026Article
- Human bone marrow derived stem cell differentiation on 3D printed bioactive glass scaffolds.Journal of materials science. Materials in medicine · 2025Article
- Biological evaluation of solutions from bioglass, bioglass modified with cobalt, and calcium hydroxide.Brazilian oral research · 2025Article
- Functional Scaffolds for Bone Tissue Regeneration: A Comprehensive Review of Materials, Methods, and Future Directions.Journal of functional biomaterials · 2024Review
- Extracellular matrix-derived materials for tissue engineering and regenerative medicine: A journey from isolation to characterization and application.Bioactive materials · 2024Review
- Tissue response and expression of interleukins (IL)-1ß, IL-6, IL-10 after pulp capping with bioglasses in mice.Brazilian oral research · 2024Article
- Cobalt-Doped Bioactive Glasses for Biomedical Applications: A Review.Materials (Basel, Switzerland) · 2023Review
- Additive Manufacturing of Polymer/Bioactive Glass Scaffolds for Regenerative Medicine: A Review.Polymers · 2023Review
- A Review on Manufacturing Processes of Biocomposites Based on Poly(α-Esters) and Bioactive Glass Fillers for Bone Regeneration.Biomimetics (Basel, Switzerland) · 2023Review
- Cobalt containing glass fibres and their synergistic effect on the HIF-1 pathway for wound healing applications.Frontiers in bioengineering and biotechnology · 2023Article
- Review
- Therapeutic approaches to activate the canonical Wnt pathway for bone regeneration.Journal of tissue engineering and regenerative medicine · 2022Review
- Robocasting of advanced ceramics: ink optimization and protocol to predict the printing parameters - A review.Heliyon · 2022Review
- In situ 4D tomography image analysis framework to follow sintering within 3D-printed glass scaffolds.Journal of the American Ceramic Society. American Ceramic Society · 2022Article
- Crosslinked Decellularized Porcine Pericardium as a Substrate for Conjunctival Reconstruction.Stem cells international · 2022Article
- Mesoporous Properties of Bioactive Glass Synthesized by Spray Pyrolysis with Various Polyethylene Glycol and Acid Additions.Polymers · 2021Article
- Bioactive glasses and electrospun composites that release cobalt to stimulate the HIF pathway for wound healing applications.Biomaterials research · 2021Article
- Finite element analysis of the performance of additively manufactured scaffolds for scapholunate ligament reconstruction.PloS one · 2021Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
Bioactive glasses (BGs) are excellent delivery systems for the sustained release of therapeutic ions and have been extensively studied in the context of bone tissue engineering. More recently, due to their osteogenic properties and expanding application to soft tissue repair, BGs have been proposed as promising materials for use at the osteochondral interface. Since hypoxia plays a critical role during cartilage formation, we sought to investigate the influence of BGs releasing the hypoxia-mimicking agent cobalt (CoBGs) on human mesenchymal stem cell (hMSC) chondrogenesis, as a novel approach that may guide future osteochondral scaffold design. The CoBG dissolution products significantly increased the level of hypoxia-inducible factor-1 alpha in hMSCs in a cobalt dose-dependent manner. Continued exposure to the cobalt-containing BG extracts significantly reduced hMSC proliferation and metabolic activity, as well as chondrogenic differentiation. Overall, this study demonstrates that prolonged exposure to cobalt warrants careful consideration for cartilage repair applications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.