Evidence map›Paper›PMID 29456243›Full record

ReviewNature reviews. Microbiology2018

Hopanoid lipids: from membranes to plant-bacteria interactions.

Brittany J Belin, Nicolas Busset, Eric Giraud, Antonio Molinaro, Alba Silipo, Dianne K Newman

Abstract readReview
In one paragraph

Review in Nature reviews. Microbiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 87 papers.

0numbers the graph read from it
0cells of the map it votes in
87citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

87 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. The Evolution of Lipids from Solvents to Substrates.Annual review of biophysics · 2026
    Review
  8. Review
  9. Oxygen-tolerant nitrogen fixation in a marine alga-colonizingApplied and environmental microbiology · 2025
    Article
  10. Article
  11. Article
  12. Article
  13. Plant biotechnology (Tokyo, Japan) · 2025
    Article
  14. Article
  15. The evolutionary history and modern diversity of triterpenoid cyclases.bioRxiv : the preprint server for biology · 2025
    Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article

27 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Brittany J BelinDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.
Nicolas BussetInstitut de Recherche pour le Développement, LSTM, UMR IRD, SupAgro, INRA, University of Montpellier, CIRAD, France.
Eric GiraudInstitut de Recherche pour le Développement, LSTM, UMR IRD, SupAgro, INRA, University of Montpellier, CIRAD, France.
Antonio MolinaroDepartment of Chemical Sciences, University of Naples Federico II, Napoli, Italy.
Alba SilipoDepartment of Chemical Sciences, University of Naples Federico II, Napoli, Italy.
Dianne K NewmanDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.

Funding

Role of hopanoid microbial lipids in a legume:microbe nitrogen-fixing symbiosisR00GM126141 · NIGMS · CARNEGIE INSTITUTION OF WASHINGTON, D.C. · PI BELIN, BRITTANY JO · 2020 to 2022
$747k
Role of hopanoid microbial lipids in a legume:microbe nitrogen-fixing symbiosisK99GM126141 · NIGMS · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI BELIN, BRITTANY JO · 2017 to 2018
$180k
NIGMS NIH HHS K99 GM126141NIGMS NIH HHS R00 GM126141
6 · The paper itself

Abstract

Lipid research represents a frontier for microbiology, as showcased by hopanoid lipids. Hopanoids, which resemble sterols and are found in the membranes of diverse bacteria, have left an extensive molecular fossil record. They were first discovered by petroleum geologists. Today, hopanoid-producing bacteria remain abundant in various ecosystems, such as the rhizosphere. Recently, great progress has been made in our understanding of hopanoid biosynthesis, facilitated in part by technical advances in lipid identification and quantification. A variety of genetically tractable, hopanoid-producing bacteria have been cultured, and tools to manipulate hopanoid biosynthesis and detect hopanoids are improving. However, we still have much to learn regarding how hopanoid production is regulated, how hopanoids act biophysically and biochemically, and how their production affects bacterial interactions with other organisms, such as plants. The study of hopanoids thus offers rich opportunities for discovery.

Indexed as

BacteriaCell MembraneLipid MetabolismLipidsPlantsLipids

Identifiers

PMID29456243
PMCPMC6087623

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.